Genome Property Definition Page
| Accession | GenProp0254 |
| Name | thiamine: TPP from HMP-PP and HET-P |
| Type | PATHWAY |
| Description | Hydroxymethylpyrimidine pyrophosphate (HMP-PP) may be obtained de novo from a purine biosynthesis intermediate or by import or salvage, then phosphorylation, of hydroxymethylpyrimidine. Likewise, hydroxyethylthiazole phosphate may be come from synthesis, import, or salvage. The two heterocylic compounds are ligated by ThiE to thiamine phosphate. Thiamine phosphate then undegoes either dephosphorylation followed by pyrophosphorylation or direct phosphorylation. This property includes both ligation and remaining steps to obtain TPP. |
| JCVI Role | Thiamine |
| Parent Property | GenProp0261: thiamin pyrophosphate (TPP) de novo biosynthesis |
| Gene Ontology Term | GO:0009228: thiamine biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| thiamine-phosphate diphosphorylase | ThiE | YES | TIGR00693 (HMM): thiamine-phosphate diphosphorylase | GO:0009228: thiamine biosynthetic process |
| TPP riboswitch (THI element) | riboswch | NO | THI (RNA) | |
| ThiL or pyrophosphokinase | toTPP | YES | TIGR01379 (HMM): thiamine-phosphate kinase TIGR01378 (HMM): thiamine pyrophosphokinase | GO:0009228: thiamine biosynthetic process GO:0009228: thiamine biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
| GenProp0253 | thiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide |