Genome Property Definition Page

Nameprotein O-heptosyltransferase with autotransporter target
DescriptionAah and TibC are protein O-heptosyltransferases that glycosylate certain repeat-rich proteins at multiple sites. Their targets are the autotransporter (T5SS) proteins AIDA (autotransporter adhesin involved in diffuse adherence) and TibA, respectively. Similar tandem gene pairs occur in Burkholderia vietnamiensis G4, Granulibacter bethesdensis CGDNIH1, Cronobacter sakazakii ATCC BAA-894, and Bradyrhizobium sp. ORS278. In Burkholderia mallei, the heptosyltransferase occurs next to BimA, an autotransporter virulence factor involved in actin-based motility, suggesting glycosylation, although BimA lacks the repeat structure recognized by model TIGR04415.
Literature References
[ 1 ]Otzen D  N for AsN - O for strOcture? A strand-loop-strand motif for prokaryotic O-glycosylation.  Mol Microbiol. 2012 Mar;83(5):879-83.  PMID 22221153

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
autotransporter strand-loop-strand O-heptosyltransferaseO_heptYESTIGR04414 (HMM): autotransporter strand-loop-strand O-heptosyltransferase
autotransporter strand-loop-strand repeatO_targYESTIGR04415 (HMM-CLUST): autotransporter passenger strand-loop-strand repeat

Child Properties
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae