Genome Property Definition Page

Namexanthine dehydrogenase
DescriptionXanthine dehydrogenase is a molydbopterin-containing enzyme. It converts xanthine, from the purine pool, to urate, which is subsequently degraded. In bacteria, the enzyme usually is encoded as a small subunit, XdhA, that contains FAD and 2Fe2S cofactors and a large subunit, XdhB, that contains the molybdopterin cofactor. The accessory protein XdhC is usually but not always encoded next to the XdhAB gene pair.
JCVI RoleOther
Parent PropertyGenProp0817: nucleotide catabolism/utilization pathways
Literature References
[ 1 ]Neumann M, Schulte M, Junemann N, Stocklein W, Leimkuhler S  Rhodobacter capsulatus XdhC Is Involved in Molybdenum Cofactor Binding and Insertion into Xanthine Dehydrogenase.  J Biol Chem. 2006 Jun 9;281(23):15701-8. Epub 2006 Apr 5.  PMID 16597619

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
xanthine dehydrogenase, 2Fe2S/FAD subunitxdhAYESTIGR02963 (HMM): xanthine dehydrogenase, small subunit
xanthine dehydrogenase, molybdopterin subunitxdhBYESTIGR02965 (HMM): xanthine dehydrogenase, molybdopterin binding subunit
xanthine dehydrogenase accessory protein XdhCxdhCYESTIGR02964 (HMM): xanthine dehydrogenase accessory protein XdhC

Parent Properties
GenProp0817nucleotide catabolism/utilization pathways

Sibling Properties
GenProp0696xanthine utilization as a source of guanine-monophosphate (GMP)
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0705xanthine dehydrogenase, bacillus type (pucABCDE)
GenProp0813pyrimidine utilization operon, RutABCDEFGR