Genome Property Definition Page
| Accession | GenProp0047 |
| Name | IPP biosynthesis via mevalonate |
| Type | PATHWAY |
| Description | Isoprenyl pyrophosphate (IPP) is synthesized in eukaryotes, archaea and certain bacteria by the mevalonate pathway (which is in contrast to the non-mevalonate pathway found more generally in prokaryotes). The bacteria containing this pathway are believed to have acquired it by lateral transfer, possible in more than one independent event [Wilding, et. al. (2000) J. Bacteriol. 182, 4319-4327]. Archaea are believed to possess a mevalonate pathway for production of IPP, but several of the steps are divergent from the known enzymes in eukaryotes and have not yet been conclusively identified [PMID: 11042147]. In eukaryotes this pathway is highly regulated to control the production of steroids which require IPP as a precursor. IPP is also required for the synthesis of menaquinone, ubiquinone, terpenoids, isoprene and prenylated proteins. The pathway begins with synthesis of (S)-3-hydroxy-3-methylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA by HMG-CoA synthase and contains 5 steps all of which are included as required elements for the assignment of the YES state for this property. Some organisms contain a pathway-specific acetoacetyl-CoA synthase which is included in the gene lists for this property but is not a required element for the determination of the property state. Other species likely obtain acetoacetyl-CoA from beta-oxidation of fatty acids or related processes. |
| JCVI Role | Other |
| Parent Property | GenProp0046: IPP biosynthesis |
| Web References | KEGG: Sterol biosynthesis IUBMB: Mevalonate Biosynthesis IUBMB: Terpenoid biosynthesis |
| Gene Ontology Term | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| acetoacetyl-CoA synthase | 1 | NO | 2.3.1.9 (ECNUM) TIGR01217 (HMM): acetoacetate-CoA ligase | |
| hydroxymethylglutaryl-CoA synthase | 2 | YES | TIGR01833 (HMM): hydroxymethylglutaryl-CoA synthase TIGR01835 (HMM): hydroxymethylglutaryl-CoA synthase TIGR00748 (HMM): putative hydroxymethylglutaryl-CoA synthase | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| hydroxymethylglutaryl-CoA reductase | 3 | YES | 1.1.1.34 (ECNUM) 1.1.1.88 (ECNUM) TIGR00533 (HMM): hydroxymethylglutaryl-CoA reductase (NADPH) TIGR00532 (HMM): hydroxymethylglutaryl-CoA reductase, degradative | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| mevalonate kinase | 4 | YES | TIGR00549 (HMM): mevalonate kinase | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| phosphomevalonate kinase | 5 | YES | TIGR01219 (HMM): phosphomevalonate kinase TIGR01220 (HMM): phosphomevalonate kinase TIGR01223 (HMM): phosphomevalonate kinase | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| diphosphomevalonate decarboxylase | 6 | YES | TIGR01240 (HMM): diphosphomevalonate decarboxylase | GO:0019287: isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0046 | IPP biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0048 | IPP biosynthesis via deoxyxylulose |