Genome Property Definition Page

NameLpt lipopolysaccharide export transenvelope protein complex
DescriptionLipopolysaccharide transport(Lpt) as it occurs in E. coli requires a complex with seven essential genes. LptBCFG spans the inner membrane, with LptBFG being an ABC transporter. LptA is periplasmic, and LptDE is in the outer membrane.
JCVI RoleBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Literature References
[ 1 ]Villa R, Martorana AM, Okuda S, Gourlay LJ, Nardini M, Sperandeo P, Deho G, Bolognesi M, Kahne D, Polissi A  The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains.  J Bacteriol. 2013 Jan 4.  PMID 23292770
[ 2 ]Bos MP, Tommassen J  The LptD chaperone LptE is not directly involved in lipopolysaccharide transport in Neisseria meningitidis.  J Biol Chem. 2011 Aug 19;286(33):28688-96.  PMID 21705335

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
LPS transport periplasmic protein LptAlptAYESTIGR03002 (HMM): lipopolysaccharide transport periplasmic protein LptA
LPS export ABC transporter ATP-binding proteinlptBYESTIGR04406 (HMM): LPS export ABC transporter ATP-binding protein
lipopolysaccharide export protein LptClptCYESPF06835 (HMM): Lipopolysaccharide-assembly, LptC-related
TIGR04409 (HMM): LPS export ABC transporter periplasmic protein LptC
LPS assembly OM complex protein LptDlptDYESPF04453 (HMM): lipopolysaccharide transport system LptD protein
LPS assembly OM complex protein LptElptEYESPF04390 (HMM): LPS export system outer membrane protein LptE
LPS export ABC permease LptFlptFYESTIGR04407 (HMM): LPS export ABC transporter permease LptF
LPS export ABC permease LptGlptGYESTIGR04408 (HMM): LPS export ABC transporter permease LptG