Genome Property Definition Page

NametRNA(Pro) cmo5UGG modification
DescriptionThe tRNA methyltransferases CmoA and CmoB, usually encoded by tandem genes, work together to complete a tRNA wobble position modification, uridine-5-oxyacetic acid (cmo5U). This modification was shown to allow a tRNA(Pro) to recognize all four proline codons. This system has a fairly narrow taxonomic range, including E. coli, in which cmoA and cmoB occur but are not essential.
JCVI RoletRNA and rRNA base modification
Parent PropertyGenProp0819: RNA metabolism
Literature References
[ 1 ]Nasvall SJ, Chen P, Bjork GR  The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo.  RNA. 2004 Oct;10(10):1662-73.  PMID 15383682
Gene Ontology TermGO:0006400: tRNA modification (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
tRNA (cmo5U34)-methyltransferasecmoAYESTIGR00740 (HMM): tRNA (cmo5U34)-methyltransferaseGO:0006400: tRNA modification
tRNA (mo5U34)-methyltransferasecmoBYESTIGR00452 (HMM): tRNA (mo5U34)-methyltransferaseGO:0006400: tRNA modification

Parent Properties
GenProp0819RNA metabolism

Sibling Properties
GenProp0258tRNA aminoacylation
GenProp0262RNA polymerase, bacterial
GenProp04826S RNA (eubacterial RNA polymerase regulator)
GenProp0677queuosine (Q-tRNA) biosynthesis from preQ0
GenProp0692selenouridine-containing tRNA
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0898RNA ligase/unknown protein pair
GenProp0948RNA repair, Hen1/Pnkp system
GenProp1060tRNA N6-threonylcarbamoyladenosine modification
GenProp108216S rRNA C1402 m(4)Cm modification