Accession | GenProp1077 |
Name | tRNA(Pro) cmo5UGG modification |
Type | SYSTEM |
Description | The tRNA methyltransferases CmoA and CmoB, usually encoded by tandem genes, work together to complete a tRNA wobble position modification, uridine-5-oxyacetic acid (cmo5U). This modification was shown to allow a tRNA(Pro) to recognize all four proline codons. This system has a fairly narrow taxonomic range, including E. coli, in which cmoA and cmoB occur but are not essential. |
JCVI Role | tRNA and rRNA base modification |
Parent Property | GenProp0819: RNA metabolism
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Literature References | [ 1 ]Nasvall SJ, Chen P, Bjork GR The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RNA. 2004 Oct;10(10):1662-73. PMID 15383682 |
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Gene Ontology Term | GO:0006400: tRNA modification (biological_process)
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