Genome Property Definition Page

NameGDP-D-mannose biosynthesis from b-D-fructose-6-phosphate
DescriptionGDP-D-mannose is used as a source of mannose when coupled with the gmm enzyme, as a source of GDP-4-keto-6-deoxymannose (GenProp0930) when coupled with the gmd enzyme (and then subsequently used to make fucose, perosamine and colicin and their derivatives). GDP-mannose may also be incorporated directly into polysaccharides such as the E. coli O8 and O9 antigens and the Klebsiella O5 antigen. The pathway consists of three acivities, an isomerase, a phosphomutase and a guanylyl transferase. The first and last steps are often catalyzed by a fusion protein (ManAC).

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
GDP-mannose mannosyl hydrolasegmmNOPF00293 (HMM-CLUST): NUDIX domain
mannose-6P-isomerasemanAYESTIGR01479 (HMM): mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
phosphomannomutasemanBYESPF00408 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, C-terminal domain
PF02878 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02880 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF02879 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
mannose-1P-guanylyltransferasemanCYESTIGR01479 (HMM): mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase