Genome Property Definition Page
| Accession | GenProp1017 |
| Name | GDP-D-mannose biosynthesis from b-D-fructose-6-phosphate |
| Type | METAPATH |
| Description | GDP-D-mannose is used as a source of mannose when coupled with the gmm enzyme, as a source of GDP-4-keto-6-deoxymannose (GenProp0930) when coupled with the gmd enzyme (and then subsequently used to make fucose, perosamine and colicin and their derivatives). GDP-mannose may also be incorporated directly into polysaccharides such as the E. coli O8 and O9 antigens and the Klebsiella O5 antigen. The pathway consists of three acivities, an isomerase, a phosphomutase and a guanylyl transferase. The first and last steps are often catalyzed by a fusion protein (ManAC). |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| GDP-mannose mannosyl hydrolase | gmm | NO | PF00293 (HMM-CLUST): NUDIX domain | |
| mannose-6P-isomerase | manA | YES | TIGR01479 (HMM): mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase | |
| phosphomannomutase | manB | YES | PF00408 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, C-terminal domain PF02878 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PF02880 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PF02879 (HMM-CLUST): phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II | |
| mannose-1P-guanylyltransferase | manC | YES | TIGR01479 (HMM): mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase |