Genome Property Definition Page

Nameelongation factor P beta-lysylation
DescriptionThis system consists of a lysyl-tRNA ligase homolog and a lysine 2,3-aminomutase homolog frequently encoded next to elongation factor P in bacteria and responsible for post-translational modification.
Literature References
[ 1 ]Bailly M, de Crecy-Lagard V  Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species.  Biol Direct. 2010 Jan 13;5:3.  PMID 20070887
[ 2 ]Yanagisawa T, Sumida T, Ishii R, Takemoto C, Yokoyama S  A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P.  Nat Struct Mol Biol. 2010 Sep;17(9):1136-43. Epub 2010 Aug 22.  PMID 20729861
[ 3 ]Park JH, Johansson HE, Aoki H, Huang BX, Kim HY, Ganoza MC, Park MH  Post-translational modification by beta-lysylation is required for activity of Escherichia coli elongation factor P (EF-P).  J Biol Chem. 2012 Jan 20;287(4):2579-90.  PMID 22128152
[ 4 ]Peil L, Starosta AL, Virumae K, Atkinson GC, Tenson T, Remme J, Wilson DN  Lys34 of translation elongation factor EF-P is hydroxylated by YfcM.  Nat Chem Biol. 2012 Aug;8(8):695-7.  PMID 22706199

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Elongation Factor P Lys34 hydroxylaseEFPepmCNOPF04315 (HMM): elongation factor P Lys34 hydroxylase
EF-P lysine aminoacylase GenXEFPgenXYESTIGR00462 (HMM): EF-P lysine aminoacylase GenX
EF-P lysine modification enzymeEFPyjeKYESTIGR03821 (HMM): EF-P beta-lysylation protein EpmB