| Accession | GenProp0958 |
| Name | D-alanyl-lipoteichoic acid biosynthesis |
| Type | SYSTEM |
| Description | The DltABCD operon, responsible for D-alanylation of LipoTeichoic acids (hence DLT) is near-universal in low-GC Gram-positive bacteria, although absent in Clostridium perfringens, Oceanobacillus iheyensis, etc. This Genome Property describes the DltABCD system, rather than LTA biosynthesis itself. Note that lipoteichoic acids (LTA), anionic polymers, are variable among species or strains, with backbones that often consist of polyglycerolphosphate (e.g. Staphylococcus aureus) but with additional modifications. LTA are covalently linked to membrane components, and differ from wall teichoic acids (WTA), such as the polyribitol phosphate WTAs in S. aureus and B. subtilis W23. |
| JCVI Role | Biosynthesis and degradation of murein sacculus and peptidoglycan |
| Literature References | [ 1 ]Osman KT, Du L, He Y, Luo Y Crystal structure of Bacillus cereus D-alanyl carrier protein ligase (DltA) in complex with ATP. J Mol Biol. 2009 May 1;388(2):345-55. Epub 2009 Mar 24. PMID 19324056
[ 2 ]Kovacs M, Halfmann A, Fedtke I, Heintz M, Peschel A, Vollmer W, Hakenbeck R, Bruckner R A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae. J Bacteriol. 2006 Aug;188(16):5797-805. PMID 16885447
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| Gene Ontology Term | GO:0070394: lipoteichoic acid metabolic process (biological_process)
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| D-alanine-D-alanyl carrier protein ligase | dltA | YES | TIGR01734 (HMM): D-alanine--poly(phosphoribitol) ligase, subunit 1 | GO:0070394: lipoteichoic acid metabolic process
|
| D-alanyl-lipoteichoic acid biosynthesis protein DltB | dltB | YES | TIGR04091 (HMM): D-alanyl-lipoteichoic acid biosynthesis protein DltB | GO:0070394: lipoteichoic acid metabolic process
|
| D-alanine-D-alanyl carrier protein | dltC | YES | TIGR01688 (HMM): D-alanine--poly(phosphoribitol) ligase, subunit 2 | GO:0070394: lipoteichoic acid metabolic process
|
| D-alanyl-lipoteichoic acid biosynthesis protein DltD | dltD | YES | TIGR04092 (HMM): D-alanyl-lipoteichoic acid biosynthesis protein DltD | GO:0070394: lipoteichoic acid metabolic process
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