Genome Property Definition Page

NameO55(Ec) antigen biosynthesis
DescriptionThe O55 O-antigen is observed in E. coli strain CB9615 and AE. The structure of the O55 antigen is a branched pentasaccharide containing one colitose sugar [1]. The O55 biosynthetic cluster encodes four sugar transferases WbgMNOP, the wzx, wzy and wzz components as well as the enzymes for the biosynthesis of GDP-L-colitose from D-fructose-6P via GDP-mannose.
JCVI RoleBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Parent PropertyGenProp0913: E. coli O-antigen monomer biosynthesis clusters
Literature References
[ 1 ]Lindberg B, Lindh F, Lonngren J  Structural studies of the O-specific side-chain of the lipopolysaccharide from Escherichia coli O 55.  Carbohydr Res. 1981 Nov 2;97(1):105-12.  PMID 7030487

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
source of GDP-colitoseGDP-ColYESGenProp0946 (GENPROP): GDP-L-colitose biosynthesis
a-D-Gal-(1->3)-b-D-GalNAc transferaseWbgMYES2753 (RULE_BASE)
a-Col-(1->2)-b-D-Gal transferaseWbgNYES2752 (RULE_BASE)
b-D-Gal-(1->3)-b-D-GlcNAc transferaseWbgOYES2747 (RULE_BASE)
b-D-GlcNAc-(1->3)-a-D-Gal transferaseWbgPYES2746 (RULE_BASE)
O55-specific transporter (flippase)wzx55YES2750 (RULE_BASE)
O55-specific polymerasewzy55YES2751 (RULE_BASE)
chain length determinant proteinwzzNOPF02706 (HMM-CLUST): chain length determinant protein

Parent Properties
GenProp0913E. coli O-antigen monomer biosynthesis clusters

Sibling Properties
GenProp0932O104(Ec) antigen biosynthesis
GenProp0949O111(Ec) antigen biosynthesis
GenProp0953O103(Ec) antigen biosynthesis
GenProp0963O2(Ec) antigen biosynthesis
GenProp1014O5(Ec) antigen biosynthesis
GenProp1018O8(Ec) antigen biosynthesis
GenProp1042O128(Ec) antigen biosynthesis