Genome Property Definition Page

Accession

GenProp0931

Name

colanic acid biosynthesis

Type

METAPATH

Description

Colanic acid is a repeat unit polysaccharide that is generally found in the Enterobacteriaceae, consisting of D-glucose, L-fucose, D-galactose and D-glucosamine. The polymer is generally functionalized with acetyl and pyruvoyl groups to a variable extent.

Literature References

[ 1 ]Stevenson G, Lan R, Reeves PR The colanic acid gene cluster of Salmonella enterica has a complex history. FEMS Microbiol Lett. 2000 Oct 1;191(1):11-6. PMID 11004393

Components

Step Name	Step Num	Required	Evidence (Method)
GDP-L-fucose biosynthesis	GDPfuc	YES	GenProp0930 (GENPROP): GDP-4-keto-6-deoxymannose biosynthesis from b-D-fructose-6-phosphate
undecaprenyl-phosphate glucose phosphotransferase	WcaJ	NO	TIGR03023 (HMM-CLUST): undecaprenyl-phosphate glucose phosphotransferase
colanic acid biosynthesis glycosyl transferase WcaA	wcaA	YES	TIGR04017 (HMM): colanic acid biosynthesis glycosyltransferase WcaA
putative colanic acid biosynthesis acetyltransferase WcaB	wcaB	YES	TIGR04016 (HMM): colanic acid biosynthesis acetyltransferase WcaB
putative colanic acid biosynthesis glycosyl transferase WcaC	wcaC	YES	TIGR04015 (HMM): colanic acid biosynthesis glycosyltransferase WcaC
putative colanic acid biosynthesis protein wcaD	wcaD	YES	TIGR04010 (HMM): putative colanic acid polymerase WcaD
colanic acid biosynthesis glycosyl transferase WcaE	wcaE	YES	TIGR04009 (HMM): colanic acid biosynthesis glycosyltransferase WcaE
colanic acid biosynthesis acetyltransferase WcaF	wcaF	YES	TIGR04008 (HMM): colanic acid biosynthesis acetyltransferase WcaF
colanic acid biosynthesis glycosyl transferase WcaI	wcaI	YES	TIGR04007 (HMM): colanic acid biosynthesis glycosyltransferase WcaI
colanic acid biosynthesis pyruvyl transferase wcaK	wcaK	YES	PF04230 (HMM-CLUST): polysaccharide pyruvyl transferase TIGR04006 (HMM): colanic acid biosynthesis pyruvyl transferase WcaK
colanic acid biosynthesis glycosyl transferase WcaL	wcaL	YES	TIGR04005 (HMM): colanic acid biosynthesis glycosyltransferase WcaL
Colanic acid biosynthesis protein wcaM	wcaM	YES	TIGR04004 (HMM): colanic acid biosynthesis protein WcaM
colanic acid export protein wza	wza	YES	SP:P0A930 (MANUAL)
low molecular weight protein-tyrosine-phosphatase wzb	wzb	YES	PF01451 (HMM-CLUST): low molecular weight phosphotyrosine protein phosphatase
tyrosine-protein kinase wzc	wzc	YES	TIGR01007 (HMM-CLUST): capsular exopolysaccharide family
lipopolysaccharide biosynthesis protein WzxC	wzxC	YES	PF01943 (HMM-CLUST): polysaccharide biosynthesis protein