Genome Property Definition Page

Namecapreomycidine biosynthesis
Description(2S,3R)-capreomycidine is made as a relatively rare precursor for non-ribosomal peptide synthesis. The first enzyme (VioC), an alpha-ketoglutarate-dependent and Fe(II)-dependent L-arginine beta-hydroxylase, produces (2S,3S)-hydroxyarginine. The second enzyme (VioD), capreomycidine synthase, converts the product to (2S,3R)-capreomycidine.
JCVI RoleBiosynthesis of natural products
Parent PropertyGenProp0063: biosynthesis
Literature References
[ 1 ]Helmetag V, Samel SA, Thomas MG, Marahiel MA, Essen LO  Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis.  FEBS J. 2009 Jul;276(13):3669-82. Epub 2009 May 26.  PMID 19490124
[ 2 ]Ju J, Ozanick SG, Shen B, Thomas MG  Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861.  Chembiochem. 2004 Sep 6;5(9):1281-5.  PMID 15368582
Gene Ontology TermGO:0042398: cellular modified amino acid biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
arginine oxygenase VioCVioCYESTIGR03946 (HMM): arginine beta-hydroxylase, Fe(II)/alpha-ketoglutarate-dependentGO:0042398: cellular modified amino acid biosynthetic process
capreomycidine synthaseVioDYESTIGR03947 (HMM): capreomycidine synthaseGO:0042398: cellular modified amino acid biosynthetic process

Parent Properties

Sibling Properties
GenProp0077natural products biosynthesis
GenProp0126amino acid biosynthesis
GenProp0184cofactor biosynthesis
GenProp0185nucleotide biosynthesis
GenProp0186storage and structural polymer biosynthesis
GenProp0197protein biosynthesis
GenProp0219spermidine biosynthesis from arginine (via agmatine)
GenProp0267osmolyte biosynthesis
GenProp0641spermidine biosynthesis from putrescine and S-adenosylmethionine
GenProp0642putrescine biosynthesis from arginine utilizing agmatinase
GenProp0643putrescine biosynthesis from arginine via ornithine
GenProp0644putrescine biosynthesis from glutamate via ornithine
GenProp0645putrescine biosynthesis
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0738agmatine to putrescine via N-carbamoylputrescine
GenProp0795carbohydrate biosynthesis
GenProp0838lipid biosynthesis
GenProp0942alkane biosynthesis, cyanobacterial
GenProp1053rSAM/selenodomain system
GenProp1056rhizo-twelve system
GenProp1057radical SAM/SPASM system GeoRSP