Genome Property Definition Page

Namecopper homeostasis system CopRS/CopABCD
DescriptionThis property describes a copper resistance (or copper homeostasis) system. The CopA/CopB pair has been shown in Xanthomonas axonopodis pathovar citri to be necessary for copper resistance. The CopC/CopD pair, occasionally found fused, has been implicated in copper resistance in some species, copper uptake in others. These two pairs commonly occur independently but occasionally occur together. CopS and CopR are copper-sensing histidine kinase and DNA-binding response regulator.
JCVI RoleAdaptations to atypical conditions
Literature References
[ 1 ] Hu YH, Wang HL, Zhang M, Sun L   Molecular analysis of the copper-responsive CopRSCD of a pathogenic Pseudomonas fluorescens strain.   J Microbiol. 2009 Jun;47(3):277-86.  PMID 19557345

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
copper-resistance protein, CopA familycopAYESTIGR01480 (HMM): copper-resistance protein, CopA family
copper-resistance protein, CopB familycopBYESPF05275 (HMM): copper resistance protein B precursor CopB
copper resistance protein, CopC familycopCYESPF04234 (HMM): CopC domain
copper resistance protein, CopD familycopDYESPF05425 (HMM): copper resistance protein D
copper resistance response regulatorcopRNO2679 (RULE_BASE)
heavy metal sensor kinasecopSYESTIGR01386 (HMM): heavy metal sensor kinase