Genome Property Definition Page

Accession

GenProp0848

Name

actin-based motility of invasive bacteria

Type

SYSTEM

Description

Actin-based motility is the process by which a bacterial pathogen uses host cell actin dynamics to achieve movement within or between cells. Bacteria known to have this capacity include Mycobacterium marinum, Burkholderia pseudomallei, and and Listeria, Rickettsia, and Shigella species. Proteins responsible for actin-dependent movement in different species share actin-binding function but may have no sequence homology from one to another.

JCVI Role

Pathogenesis

Parent Property

GenProp0073: cell motility

Literature References

[ 1 ] Gouin E, Welch MD, Cossart P   Actin-based motility of intracellular pathogens.   Curr Opin Microbiol. 2005 Feb;8(1):35-45.  PMID 15694855
[ 2 ] Stevens JM, Galyov EE, Stevens MP   Actin-dependent movement of bacterial pathogens.   Nat Rev Microbiol. 2006 Feb;4(2):91-101.  PMID 16415925
[ 3 ] Kocks C, Marchand JB, Gouin E, d'Hauteville H, Sansonetti PJ, Carlier MF, Cossart P   The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively.   Mol Microbiol. 1995 Nov;18(3):413-23.  PMID 8748026

Gene Ontology Term

GO:0070358: actin polymerization-dependent cell motility (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
actin-based motility protein	actin	YES	PF05058 (HMM): protein ActA 2401 (RULE_BASE) 2371 (RULE_BASE)	GO:0070358: actin polymerization-dependent cell motility GO:0070358: actin polymerization-dependent cell motility GO:0070358: actin polymerization-dependent cell motility

Parent Properties

Accession	Name
GenProp0073	cell motility

Sibling Properties

Accession	Name
GenProp0007	flagella
GenProp0026	chemotaxis
GenProp0056	type IV pilus
GenProp0781	gliding motility, Bacteroidetes type