Genome Property Definition Page

Nameheme uptake system, NEAT-domain mediated
DescriptionThis system is found in certain lineages of the Bacillus/Clostridium group, including a number of pathogenic species. In order to obtain iron, this system utilizes a number of NEAT domain (PF05031) containing proteins to scavenge heme from host hemoproteins and convey them across the cell wall to an ABC transporter in the cytoplasmic membrane. Cell wall localization of these components is generally mediated by sortases, SrtB being particularly critical to this system in many organisms. Heme is often oxidized to biliverdin by heme oxygenases in the cytoplasm, releasing iron. Genes of this system are generally given "isd" gene symbols where isd stands for Iron-regulated Surface Determinant proteins.
Parent PropertyGenProp0180: small molecule transport
GenProp0820: iron metabolism
Literature References
[ 1 ] Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ  Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus.   J Biol Chem. 2008 Aug 1.  PMID 18676371
[ 2 ] Grigg JC, Vermeiren CL, Heinrichs DE, Murphy ME   Haem recognition by a Staphylococcus aureus NEAT domain.   Mol Microbiol. 2007 Jan;63(1):139-49.  PMID 17229211
[ 3 ] Maresso AW, Garufi G, Schneewind O   Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin.   PLoS Pathog. 2008 Aug 22;4(8):e1000132.  PMID 18725935
[ 4 ] Skaar EP, Gaspar AH, Schneewind O   IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus.   J Biol Chem. 2004 Jan 2;279(1):436-43. Epub 2003 Oct 21.  PMID 14570922
Gene Ontology TermGO:0015886: heme transport (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
heme oxygenaseHOYESPF03992 (HMM): antibiotic biosynthesis monooxygenase
PF01126 (HMM): heme oxygenase
GO:0015886: heme transport
GO:0015886: heme transport
heme ABC transporter, heme-binding protein IsdEIsdEYESTIGR03659 (HMM): heme ABC transporter, heme-binding protein isdEGO:0015886: heme transport
heme ABC transporter, permease protein IsdFIsdFYESPF01032 (HMM-CLUST): iron chelate uptake ABC transporter, FeCT family, permease proteinGO:0015886: heme transport
NEAT-domain proteinsNEATYESPF05031 (HMM): iron transport-associated domainGO:0015886: heme transport
heme ABC transporter, ATP-binding proteinisdDNOPF00005 (HMM-CLUST): ABC transporter, ATP-binding proteinGO:0015886: heme transport
multi-NEAT, srt-signal componentmNssNOTIGR03658 (HMM): haptoglobin-binding heme uptake protein HarA
TIGR03657 (HMM): heme uptake protein IsdB
GO:0015886: heme transport
GO:0015886: heme transport
single-NEAT domain (secreted?) componentsNNONEAT domain w/out surface anch (MANUAL)
GO:0015886: heme transport
single-NEAT, srt-signal componentsNssYESTIGR03656 (HMM): heme uptake protein IsdC
2352 (RULE_BASE)
GO:0015886: heme transport
GO:0015886: heme transport

Parent Properties
GenProp0180small molecule transport
GenProp0820iron metabolism

Sibling Properties
GenProp0119PTS transport system
GenProp0129Na+-translocating NADH-quinone reductase
GenProp0135NADH dehydrogenase I
GenProp0172Potassium-transporting ATPase KdpFABC
GenProp0176TRAP-T (tripartite ATP-independent periplasmic transporters) family transporters
GenProp0190phosphate ABC transporter (pstSCAB-phoU)
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0192molybdate ABC transporter
GenProp0236phosphonates ABC transport
GenProp0252thiamine/TPP ABC transporter ThiBPQ
GenProp0279cobalt import systems
GenProp0494nickel import ABC transporter
GenProp0542Tol-Pal system
GenProp0543TonB-dependent transport
GenProp0651ectoine ABC transporter EhuABCD
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp07122-aminoethylphosphonate (AEP) ABC transporter, type I, PhnSTUV
GenProp07212-aminoethylphosphonate (AEP) ABC transporter, type II
GenProp0743urea ABC transporter UrtABCDE
GenProp0748choline ABC transporter, ChoXWV family
GenProp0749choline sulfate utilization
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0873ion-motive antiporter cycles
GenProp0140iron-sulfur cluster assembly systems
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0222protoheme from protoporphyrin IX
GenProp0627gene pair involved in iron and oxygen metabolism
GenProp0770siderophore biosynthesis
GenProp0774ferric citrate transport system
GenProp0961heme metabolism pair HutWX