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Genome Property Definition Page

Accession	GenProp0828
Name	heme uptake system, NEAT-domain mediated
Type	SYSTEM
Description	This system is found in certain lineages of the Bacillus/Clostridium group, including a number of pathogenic species. In order to obtain iron, this system utilizes a number of NEAT domain (PF05031) containing proteins to scavenge heme from host hemoproteins and convey them across the cell wall to an ABC transporter in the cytoplasmic membrane. Cell wall localization of these components is generally mediated by sortases, SrtB being particularly critical to this system in many organisms. Heme is often oxidized to biliverdin by heme oxygenases in the cytoplasm, releasing iron. Genes of this system are generally given "isd" gene symbols where isd stands for Iron-regulated Surface Determinant proteins.
Parent Property	GenProp0180: small molecule transport GenProp0820: iron metabolism
Literature References	[ 1 ] Muryoi N, Tiedemann MT, Pluym M, Cheung J, Heinrichs DE, Stillman MJ  Demonstration of the iron-regulated surface determinant heme transfer pathway in Staphylococcus aureus.   J Biol Chem. 2008 Aug 1.  PMID 18676371 [ 2 ] Grigg JC, Vermeiren CL, Heinrichs DE, Murphy ME   Haem recognition by a Staphylococcus aureus NEAT domain.   Mol Microbiol. 2007 Jan;63(1):139-49.  PMID 17229211 [ 3 ] Maresso AW, Garufi G, Schneewind O   Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin.   PLoS Pathog. 2008 Aug 22;4(8):e1000132.  PMID 18725935 [ 4 ] Skaar EP, Gaspar AH, Schneewind O   IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus.   J Biol Chem. 2004 Jan 2;279(1):436-43. Epub 2003 Oct 21.  PMID 14570922
Gene Ontology Term	GO:0015886: heme transport (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
heme oxygenase	HO	YES	PF03992 (HMM): antibiotic biosynthesis monooxygenase PF01126 (HMM): heme oxygenase	GO:0015886: heme transport GO:0015886: heme transport
heme ABC transporter, heme-binding protein IsdE	IsdE	YES	TIGR03659 (HMM): heme ABC transporter, heme-binding protein isdE	GO:0015886: heme transport
heme ABC transporter, permease protein IsdF	IsdF	YES	PF01032 (HMM-CLUST): iron chelate uptake ABC transporter, FeCT family, permease protein	GO:0015886: heme transport
NEAT-domain proteins	NEAT	YES	PF05031 (HMM): iron transport-associated domain	GO:0015886: heme transport
heme ABC transporter, ATP-binding protein	isdD	NO	PF00005 (HMM-CLUST): ABC transporter, ATP-binding protein	GO:0015886: heme transport
multi-NEAT, srt-signal component	mNss	NO	TIGR03658 (HMM): haptoglobin-binding heme uptake protein HarA TIGR03657 (HMM): heme uptake protein IsdB	GO:0015886: heme transport GO:0015886: heme transport
single-NEAT domain (secreted?) component	sN	NO	NEAT domain w/out surface anch (MANUAL)	GO:0015886: heme transport
single-NEAT, srt-signal component	sNss	YES	TIGR03656 (HMM): heme uptake protein IsdC 2352 (RULE_BASE)	GO:0015886: heme transport GO:0015886: heme transport

Parent Properties

Accession	Name
GenProp0180	small molecule transport
GenProp0820	iron metabolism

Sibling Properties

Accession	Name
GenProp0119	PTS transport system
GenProp0129	Na+-translocating NADH-quinone reductase
GenProp0135	NADH dehydrogenase I
GenProp0172	Potassium-transporting ATPase KdpFABC
GenProp0176	TRAP-T (tripartite ATP-independent periplasmic transporters) family transporters
GenProp0190	phosphate ABC transporter (pstSCAB-phoU)
GenProp0191	sulfate/thiosulfate ABC transporter
GenProp0192	molybdate ABC transporter
GenProp0236	phosphonates ABC transport
GenProp0252	thiamine/TPP ABC transporter ThiBPQ
GenProp0279	cobalt import systems
GenProp0494	nickel import ABC transporter
GenProp0542	Tol-Pal system
GenProp0543	TonB-dependent transport
GenProp0651	ectoine ABC transporter EhuABCD
GenProp0693	fructose utilization as fructose-1,6-bisphosphate
GenProp0694	glucose utilization as fructose-1,6-bisphosphate
GenProp0712	2-aminoethylphosphonate (AEP) ABC transporter, type I, PhnSTUV
GenProp0721	2-aminoethylphosphonate (AEP) ABC transporter, type II
GenProp0743	urea ABC transporter UrtABCDE
GenProp0748	choline ABC transporter, ChoXWV family
GenProp0749	choline sulfate utilization
GenProp0853	lantibiotic system, gallidermin/epidermin family
GenProp0873	ion-motive antiporter cycles
GenProp0140	iron-sulfur cluster assembly systems
GenProp0194	siroheme biosynthesis from uroporphrinogen-III
GenProp0222	protoheme from protoporphyrin IX
GenProp0627	gene pair involved in iron and oxygen metabolism
GenProp0770	siderophore biosynthesis
GenProp0774	ferric citrate transport system
GenProp0961	heme metabolism pair HutWX