| Accession | GenProp0773 |
| Name | aerobactin biosynthesis |
| Type | SYSTEM |
| Description | Aerobactin is a siderophore of the hydroxamate class. Four biosynthetic genes, iucABCD (Iron Uptake Chelate) synthesize it from two lysines and a citrate. IucD is L-lysine 6-monooxygenase (NADPH) (EC 1.14.13.59). IucB is N(6)-hydroxylysine O-acetyltransferase (EC 2.3.1.102). The actions of IucA, followed by IucC, attach two molecules of 6-N-acetyl-6-N-hydroxy-L-lysine to a citrate backbone; it is convenient, for now, to regard these two steps together as 6.3.2.27. |
| JCVI Role | Siderophores |
| Parent Property | GenProp0770: siderophore biosynthesis
|
| Literature References | [ 1 ] de Lorenzo V, Neilands JB Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli. J Bacteriol. 1986 Jul;167(1):350-5. PMID 3087960
[ 2 ] Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis. Microbiology. 2007 Jul;153(Pt 7):2332-41. PMID 17600077
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| Gene Ontology Term | GO:0019270: aerobactin biosynthetic process (biological_process)
GO:0019271: aerobactin transport (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| aerobactin synthase, IucA component | iucA | YES | 2205 (RULE_BASE)
| GO:0019270: aerobactin biosynthetic process
|
| N(6)-hydroxylysine O-acetyltransferase | iucB | YES | 2210 (RULE_BASE)
| GO:0019270: aerobactin biosynthetic process
|
| aerobactin synthase, iucC component | iucC | YES | 2206 (RULE_BASE)
| GO:0019270: aerobactin biosynthetic process
|
| L-lysine 6-monooxygenase (NADPH) | iucD | YES | 2211 (RULE_BASE)
| GO:0019270: aerobactin biosynthetic process
|
| ferric aerobactin receptor IutA | iutA | YES | 2209 (RULE_BASE)
| GO:0019271: aerobactin transport
|
