Genome Property Definition Page

Nameaerobactin biosynthesis
DescriptionAerobactin is a siderophore of the hydroxamate class. Four biosynthetic genes, iucABCD (Iron Uptake Chelate) synthesize it from two lysines and a citrate. IucD is L-lysine 6-monooxygenase (NADPH) (EC IucB is N(6)-hydroxylysine O-acetyltransferase (EC The actions of IucA, followed by IucC, attach two molecules of 6-N-acetyl-6-N-hydroxy-L-lysine to a citrate backbone; it is convenient, for now, to regard these two steps together as
JCVI RoleSiderophores
Parent PropertyGenProp0770: siderophore biosynthesis
Literature References
[ 1 ] de Lorenzo V, Neilands JB   Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli.   J Bacteriol. 1986 Jul;167(1):350-5.  PMID 3087960
[ 2 ] Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD   Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis.   Microbiology. 2007 Jul;153(Pt 7):2332-41.  PMID 17600077
Gene Ontology TermGO:0019270: aerobactin biosynthetic process (biological_process)
GO:0019271: aerobactin transport (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
aerobactin synthase, IucA componentiucAYES2205 (RULE_BASE)
GO:0019270: aerobactin biosynthetic process
N(6)-hydroxylysine O-acetyltransferaseiucBYES2210 (RULE_BASE)
GO:0019270: aerobactin biosynthetic process
aerobactin synthase, iucC componentiucCYES2206 (RULE_BASE)
GO:0019270: aerobactin biosynthetic process
L-lysine 6-monooxygenase (NADPH)iucDYES2211 (RULE_BASE)
GO:0019270: aerobactin biosynthetic process
ferric aerobactin receptor IutAiutAYES2209 (RULE_BASE)
GO:0019271: aerobactin transport

Parent Properties
GenProp0770siderophore biosynthesis

Sibling Properties
GenProp0771enterobactin (enterochelin) biosynthesis
GenProp0772yersiniabactin biosynthesis
GenProp0775mycobactin biosynthesis
GenProp0776pyochelin biosynthesis
GenProp0777staphylobactin biosynthesis
GenProp0783petrobactin biosynthesis