Genome Property Definition Page

Nameyersiniabactin biosynthesis
DescriptionYersiniabactin is a siderophore found in a number of enterobacteria, including Yersinia pestis and some strains of Escherichia coli. Its biosynthesis and utilization may coexist in an organism with other siderophore systems such as enterobactin and aerobactin. Yersiniabactin is made from salicylate, three cysteines, and a malonyl group by a nonribosomal peptide synthetase/polyketide synthase.
JCVI RoleSiderophores
Parent PropertyGenProp0770: siderophore biosynthesis
Literature References
[ 1 ] Miller DA, Luo L, Hillson N, Keating TA, Walsh CT   Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis.   Chem Biol. 2002 Mar;9(3):333-44.  PMID 11927258
[ 2 ] Bultreys A, Gheysen I, de Hoffmann E   Yersiniabactin production by Pseudomonas syringae and Escherichia coli, and description of a second yersiniabactin locus evolutionary group.   Appl Environ Microbiol. 2006 Jun;72(6):3814-25.  PMID 16751485
Gene Ontology TermGO:0019290: siderophore biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
yersiniabactin transcriptional regulator YbtAybtANO2159 (RULE_BASE)
salicyl-AMP ligase, yersiniabactin biosyntheticybtEYES2163 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
salicylate synthase, yersiniabactin systemybtSYES2167 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
yersiniabactin biosynthesis thioesterase YbtTybtTYES2165 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
yersiniabactin synthetase, YbtU componentybtUYES2164 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
yersiniabactin region putative transporter YbtXybtXNO2166 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
yersiniabactin synthetase, HMWP1 componentybt_HM1YES2162 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
yersiniabactin synthetase, HMWP2 componentybt_HM2YES2161 (RULE_BASE)
GO:0019290: siderophore biosynthetic process

Parent Properties
GenProp0770siderophore biosynthesis

Sibling Properties
GenProp0771enterobactin (enterochelin) biosynthesis
GenProp0773aerobactin biosynthesis
GenProp0775mycobactin biosynthesis
GenProp0776pyochelin biosynthesis
GenProp0777staphylobactin biosynthesis
GenProp0783petrobactin biosynthesis