| Accession | GenProp0772 |
| Name | yersiniabactin biosynthesis |
| Type | SYSTEM |
| Description | Yersiniabactin is a siderophore found in a number of enterobacteria, including Yersinia pestis and some strains of Escherichia coli. Its biosynthesis and utilization may coexist in an organism with other siderophore systems such as enterobactin and aerobactin. Yersiniabactin is made from salicylate, three cysteines, and a malonyl group by a nonribosomal peptide synthetase/polyketide synthase. |
| JCVI Role | Siderophores |
| Parent Property | GenProp0770: siderophore biosynthesis
|
| Literature References | [ 1 ] Miller DA, Luo L, Hillson N, Keating TA, Walsh CT Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. Chem Biol. 2002 Mar;9(3):333-44. PMID 11927258
[ 2 ] Bultreys A, Gheysen I, de Hoffmann E Yersiniabactin production by Pseudomonas syringae and Escherichia coli, and description of a second yersiniabactin locus evolutionary group. Appl Environ Microbiol. 2006 Jun;72(6):3814-25. PMID 16751485
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| Gene Ontology Term | GO:0019290: siderophore biosynthetic process (biological_process)
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| yersiniabactin transcriptional regulator YbtA | ybtA | NO | 2159 (RULE_BASE)
| |
| salicyl-AMP ligase, yersiniabactin biosynthetic | ybtE | YES | 2163 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
| salicylate synthase, yersiniabactin system | ybtS | YES | 2167 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
| yersiniabactin biosynthesis thioesterase YbtT | ybtT | YES | 2165 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
| yersiniabactin synthetase, YbtU component | ybtU | YES | 2164 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
| yersiniabactin region putative transporter YbtX | ybtX | NO | 2166 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
| yersiniabactin synthetase, HMWP1 component | ybt_HM1 | YES | 2162 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
| yersiniabactin synthetase, HMWP2 component | ybt_HM2 | YES | 2161 (RULE_BASE)
| GO:0019290: siderophore biosynthetic process
|
