| Accession | GenProp0771 |
| Name | enterobactin (enterochelin) biosynthesis |
| Type | SYSTEM |
| Description | Enterobactin, also called enterochelin, is a catecholate siderophore found in most enterobacterial strains, where it may exist alongside other siderophore systems. It is a a cyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)serine. The proteins EntA, EntB, and EntC produce 2,3-dihydroxybenzoate. Enterobactin synthetase is a non-ribosomal peptide synthase (NRPS) that builds enterobactin from three molecules of 2,3-dihydroxybenzoate and three of L-serine. The components of the enterobactin synthetase are designated EntB, EntE, and EntF. EntD is an accessory protein that phosphopantetheinylates EntB (PMID:9214294). EntH is a proofreading enzyme, a thioesterase, while EntS is a specific exporter across the plasma membrane. |
| JCVI Role | Siderophores |
| Parent Property | GenProp0770: siderophore biosynthesis
|
| Gene Ontology Term | GO:0009239: enterobactin biosynthetic process (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase | entA | YES | 2147 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| isochorismatase/enterobactin synthetase, component EntB | entBG | YES | 2150 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| isochorismate synthase EntC | entC | YES | 2151 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| 4'-phosphopantetheinyl transferase EntD | entD | YES | 2152 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| enterobactin synthetase, (2,3-dihydroxybenzoyl)adenylate synthase component | entE | YES | 2155 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| enterobactin synthetase, component EntF | entF | YES | 2156 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| enterobactin biosynthesis proofreading thioesterase EntH | entH | NO | 2149 (RULE_BASE)
| GO:0009239: enterobactin biosynthetic process
|
| enterobactin exporter EntS | entS | YES | 2153 (RULE_BASE)
| |
