Genome Property Definition Page

Nameenterobactin (enterochelin) biosynthesis
DescriptionEnterobactin, also called enterochelin, is a catecholate siderophore found in most enterobacterial strains, where it may exist alongside other siderophore systems. It is a a cyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)serine. The proteins EntA, EntB, and EntC produce 2,3-dihydroxybenzoate. Enterobactin synthetase is a non-ribosomal peptide synthase (NRPS) that builds enterobactin from three molecules of 2,3-dihydroxybenzoate and three of L-serine. The components of the enterobactin synthetase are designated EntB, EntE, and EntF. EntD is an accessory protein that phosphopantetheinylates EntB (PMID:9214294). EntH is a proofreading enzyme, a thioesterase, while EntS is a specific exporter across the plasma membrane.
JCVI RoleSiderophores
Parent PropertyGenProp0770: siderophore biosynthesis
Gene Ontology TermGO:0009239: enterobactin biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenaseentAYES2147 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
isochorismatase/enterobactin synthetase, component EntBentBGYES2150 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
isochorismate synthase EntCentCYES2151 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
4'-phosphopantetheinyl transferase EntDentDYES2152 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
enterobactin synthetase, (2,3-dihydroxybenzoyl)adenylate synthase componententEYES2155 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
enterobactin synthetase, component EntFentFYES2156 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
enterobactin biosynthesis proofreading thioesterase EntHentHNO2149 (RULE_BASE)
GO:0009239: enterobactin biosynthetic process
enterobactin exporter EntSentSYES2153 (RULE_BASE)

Parent Properties
GenProp0770siderophore biosynthesis

Sibling Properties
GenProp0772yersiniabactin biosynthesis
GenProp0773aerobactin biosynthesis
GenProp0775mycobactin biosynthesis
GenProp0776pyochelin biosynthesis
GenProp0777staphylobactin biosynthesis
GenProp0783petrobactin biosynthesis