Genome Property Definition Page
| Accession | GenProp0769 |
| Name | Neisseria lipooligosaccharide, lacto-N-neotetraose biosynthesis |
| Type | PATHWAY |
| Description | In Neisseria, lipooligosaccharide (LOS) is a highly variable virulence determinant. This Genome Property describes a set of three glycosyltransferases (lgtA, lgtB, and lgtE) that work together in the formation of lacto-N-neotetraose, a component of the LOS alpha chain. Additional genes may also be present and lead to different types of LOS. |
| JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0009103: lipopolysaccharide biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| lacto-N-neotetraose biosynthesis glycosyl transferase LgtA | lgtA | YES | 2122 (RULE_BASE) | GO:0009103: lipopolysaccharide biosynthetic process |
| lacto-N-neotetraose biosynthesis glycosyl transferase LgtB | lgtB | YES | 2120 (RULE_BASE) | GO:0009103: lipopolysaccharide biosynthetic process |
| lacto-N-neotetraose biosynthesis glycosyl transferase LgtE | lgtE | YES | 2121 (RULE_BASE) | GO:0009103: lipopolysaccharide biosynthetic process |