| Accession | GenProp0765 |
| Name | glycerol fermentation to 1,3-propanediol, using glycerol dehydratase |
| Type | PATHWAY |
| Description | Glycerol can be converted anaerobically to 1,3-propanediol in two steps. Glycerol dehydratase (EC 4.2.1.30), which needs B12, removes a water and gives 3-hydroxypropionaldehyde. 1,3-propanediol dehydrogenase then converts 3-hydroxypropionaldehyde and NADH 1,3-propanediol and NAD+. Model species for this pathway include Citrobacter freundii, Klebsiella pneumoniae, and Clostridium pasteurianum. |
| JCVI Role | Other |
| Parent Property | GenProp0298: fermentation
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| Literature References | [ 1 ] Seifert C, Bowien S, Gottschalk G, Daniel R Identification and expression of the genes and purification and characterization of the gene products involved in reactivation of coenzyme B12-dependent glycerol dehydratase of Citrobacter freundii. Eur J Biochem. 2001 Apr;268(8):2369-78. PMID 11298756
[ 2 ] Macis L, Daniel R, Gottschalk G Properties and sequence of the coenzyme B12-dependent glycerol dehydratase of Clostridium pasteurianum. FEMS Microbiol Lett. 1998 Jul 1;164(1):21-8. PMID 9675846
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| glycerol dehydratase, alpha subunit | dhaB | YES | 2099 (RULE_BASE)
| |
| glycerol dehydratase, beta subunit | dhaC | YES | 2098 (RULE_BASE)
| |
| glycerol dehydratase, gamma subunit | dhaE | YES | 2096 (RULE_BASE)
| |
| glycerol dehydratase reactivase, large subunit | dhaF | YES | 2097 (RULE_BASE)
| |
| glycerol dehydratase reactivase, small subunit | dhaG | YES | 2095 (RULE_BASE)
| |
| 1,3-propanediol dehydrogenase | dhaT | YES | 2094 (RULE_BASE)
| |
