Genome Property Definition Page

Nameglycerol fermentation to 1,3-propanediol, using glycerol dehydratase
DescriptionGlycerol can be converted anaerobically to 1,3-propanediol in two steps. Glycerol dehydratase (EC, which needs B12, removes a water and gives 3-hydroxypropionaldehyde. 1,3-propanediol dehydrogenase then converts 3-hydroxypropionaldehyde and NADH 1,3-propanediol and NAD+. Model species for this pathway include Citrobacter freundii, Klebsiella pneumoniae, and Clostridium pasteurianum.
JCVI RoleOther
Parent PropertyGenProp0298: fermentation
Literature References
[ 1 ] Seifert C, Bowien S, Gottschalk G, Daniel R   Identification and expression of the genes and purification and characterization of the gene products involved in reactivation of coenzyme B12-dependent glycerol dehydratase of Citrobacter freundii.   Eur J Biochem. 2001 Apr;268(8):2369-78.  PMID 11298756
[ 2 ] Macis L, Daniel R, Gottschalk G   Properties and sequence of the coenzyme B12-dependent glycerol dehydratase of Clostridium pasteurianum.   FEMS Microbiol Lett. 1998 Jul 1;164(1):21-8.  PMID 9675846

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glycerol dehydratase, alpha subunitdhaBYES2099 (RULE_BASE)
glycerol dehydratase, beta subunitdhaCYES2098 (RULE_BASE)
glycerol dehydratase, gamma subunitdhaEYES2096 (RULE_BASE)
glycerol dehydratase reactivase, large subunitdhaFYES2097 (RULE_BASE)
glycerol dehydratase reactivase, small subunitdhaGYES2095 (RULE_BASE)
1,3-propanediol dehydrogenasedhaTYES2094 (RULE_BASE)

Parent Properties

Sibling Properties
GenProp0272pyruvate fermentation to acetoin
GenProp0763nicotinate fermentation to pyruvate and propionate