Genome Property Definition Page
Accession | GenProp0760 | |
Name | putrescine degradation to GABA via gamma-glutamylation | |
Type | PATHWAY | |
Description | Four sequential enzymatic steps catalyze the degradation of putrescine to GABA (gamma-aminobutyrate) in Escherichia coli and related species by way of gamma-glutamylated intermediates. This modification prevents occurrence of the unstable compound gamma-aminobutyraldhyde as an intermediate. Note that mammalian cells appear to achieve a similar protection for putrescine degradation by acetylation rather than gamma-glutamylation. Genes for regulation of the system (puuR, previously ycjC), for import of putrescine (puuP, previously ycjJ), and for the conversion of GABA to succination semialdehyde (goaG) and then succinate (gabD) are associated with this pathway but not modeled at present as part of this Genome Property. | |
JCVI Role | Amino acids and amines | |
Parent Property | GenProp0142: catabolism | |
Literature References |
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Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
glutamate--putrescine ligase | puuA | YES | 60 (RULE_BASE) | |
gamma-glutamylputrescine oxidase | puuB | YES | 61 (RULE_BASE) | |
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase | puuC | YES | 62 (RULE_BASE) | |
gamma-glutamyl-gamma-aminobutyrate hydrolase | puuD | YES | 63 (RULE_BASE) |
Parent Properties
Accession | Name |
---|---|
GenProp0142 | catabolism |
Sibling Properties
Accession | Name |
---|---|
GenProp0055 | polyhydroxyalkanoic acids |
GenProp0141 | galactose-6-phosphate degradation via tagatose-6-phosphate |
GenProp0156 | cyanophycin-like storage polymers |
GenProp0168 | glycogen system |
GenProp0210 | phenylacetic acid catabolism |
GenProp0231 | 4-hydroxyphenylacetate degradation |
GenProp0233 | GABA utilization |
GenProp0238 | 2-aminoethylphosphonate catabolism to acetaldehyde |
GenProp0239 | propionyl-CoA catabolism |
GenProp0241 | phosphonate catabolism |
GenProp0271 | trehalose utilization |
GenProp0272 | pyruvate fermentation to acetoin |
GenProp0273 | protocatechuate degradation to beta-ketoadipate |
GenProp0283 | beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA |
GenProp0294 | ethanolamine degradation proteinaceous organelle |
GenProp0457 | rhamnose catabolism |
GenProp0458 | fucose catabolism |
GenProp0461 | utilization of deoxynucleosides |
GenProp0653 | ectoine catabolism |
GenProp0674 | malonate decarboxylase |
GenProp0686 | allantoin catabolism to glyoxalate and urea |
GenProp0687 | allantoin catabolism to oxamate and carbamoyl-phosphate |
GenProp0688 | urate catabolism to allantoin |
GenProp0691 | glycolysis |
GenProp0693 | fructose utilization as fructose-1,6-bisphosphate |
GenProp0694 | glucose utilization as fructose-1,6-bisphosphate |
GenProp0700 | purine catabolism via urate, xanthine and allantoin |
GenProp0702 | benzoyl-CoA reductase |
GenProp0703 | 4-hydroxybenzoyl-CoA reductase |
GenProp0706 | cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway |
GenProp0708 | catechol meta-cleavage pathway |
GenProp0709 | benzoate catabolism BoxABC pathway |
GenProp0711 | catechol ortho-cleavage upper pathway |
GenProp0714 | galactarate utilization via tartronate semi-aldehyde |
GenProp0715 | galactarate utilization via 2-oxoglutarate semialdehyde |
GenProp0716 | glucarate utilization via tartronate semi-aldehyde |
GenProp0717 | glucarate utilization via 2-oxoglutarate semialdehyde |
GenProp0718 | oxalate degradation |
GenProp0734 | amino acid catabolism |
GenProp0749 | choline sulfate utilization |
GenProp0763 | nicotinate fermentation to pyruvate and propionate |
GenProp0810 | encapsulin proteinaceous organelle |
GenProp0813 | pyrimidine utilization operon, RutABCDEFGR |
GenProp0902 | quinohemoprotein amine dehydrogenase |
GenProp1071 | myo-inositol catabolism |
GenProp1072 | cyanase system |
GenProp1076 | choline TMA-lyase system |