Genome Property Definition Page
| Accession | GenProp0747 |
| Name | adenosine monophosphate (AMP) biosynthesis from inosine monophosphate (IMP) |
| Type | PATHWAY |
| Description | This two-step pathway in purine biosynthesis begins with IMP (inosine monophosphate), a branch point in purine de novo biosynthesis. Adenylosuccinate synthetase (EC 6.3.4.4), product of the PurA gene, catalyzes the first committed step to AMP. Adenylosuccinate lyase (EC 4.3.2.2), product of the purB gene, catalyzes the second and final step, but it also catalyzes the eighth step in IMP biosynthesis. |
| JCVI Role | Purine ribonucleotide biosynthesis |
| Parent Property | GenProp0185: nucleotide biosynthesis |
| Gene Ontology Term | GO:0006167: AMP biosynthetic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| adenylosuccinate synthetase | purA | YES | TIGR00184 (HMM): adenylosuccinate synthase | GO:0006167: AMP biosynthetic process |
| adenylosuccinate lyase | purB | YES | TIGR00928 (HMM): adenylosuccinate lyase | GO:0006167: AMP biosynthetic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0185 | nucleotide biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0110 | purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate |
| GenProp0187 | pyrimidine (uridine-5'-phosphate) de novo biosynthesis |
| GenProp0673 | ribulose monophosphate pathway |
| GenProp0696 | xanthine utilization as a source of guanine-monophosphate (GMP) |
| GenProp0697 | guanine monophosphate (GMP) biosynthesis from inosine monophosphate (IMP) |