Genome Property Definition Page

Nameiron-sulfur cluster assembly CsdA-CsdE system
DescriptionThe heteromeric complex of CsdA and CsdE plays a role in iron-sulfur (Fe-S) cluster biosynthesis, as do the better-known systems ISC, SUF, and NIF. CdsA, a homolog of SufS, IscS, and NifS, is a cysteine desulfurase catalytic subunit. CdsE, a SufE homolog, physically interacts and accepts a sulfur at Cys-61 (numbered as in Escherichia coli). In contrast to sulfur-accepting components such as NifU and IscU, CsdE does not bind iron and is not viewed as a scaffold on which Fe-S cluster biosynthesis can be completed prior to transfer to other proteins. Rather, this simplicity of this system may reflect a limited role for the maturation of specific Fe-S cluster-containing proteins.
JCVI RoleOther
Parent PropertyGenProp0140: iron-sulfur cluster assembly systems
Literature References
[ 1 ]Loiseau L, Ollagnier-de Choudens S, Lascoux D, Forest E, Fontecave M, Barras F  Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli.  J Biol Chem. 2005 Jul 22;280(29):26760-9.  PMID 15901727
Gene Ontology TermGO:0016226: iron-sulfur cluster assembly (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
cysteine desulfurase, catalytic subunit CdsAFeSCsdAYESTIGR03392 (HMM): cysteine desulfurase, catalytic subunit CsdAGO:0016226: iron-sulfur cluster assembly
cysteine desulfurase, sulfur acceptor subunit CsdEFeSCsdEYESTIGR03391 (HMM): cysteine desulfurase, sulfur acceptor subunit CsdEGO:0016226: iron-sulfur cluster assembly

Parent Properties
GenProp0140iron-sulfur cluster assembly systems

Sibling Properties
GenProp0137iron-sulfur cluster assembly SUF system
GenProp0138iron-sulfur cluster assembly iscSUA-hscBA-fdx system
GenProp0742iron-sulfur cluster assembly NIF system