Genome Property Definition Page

Nameglyoxalate conversion to phosphoglycerate
DescriptionGlyoxalate is a common intermediate produced by a number of catabolic and anapleurotic pathways, notably the breakdown for allantoate, proline and glycine and the glyoxalate shunt. This pathway is initiated by the incorporation of carbon dioxide utilizing the TPP-dependent enzyme, tartronate-semialdehyde synthase (aka glyoxalate carbo-ligase, gcl). Note that this is not a carbon-fixation pathway. For instance, in the case of allantoate catabolism, the production of glyoxalate also produces one or more molecules of carbon dioxide. Intermediates in this pathway (tartronate semialdehyde, and glycerate) may be diverted to other final products involved, for instance in covactor biosynthesis. Phosphoglycerate may be put to a large number of metabolic uses.
JCVI RoleOther
Parent PropertyGenProp0072: central intermediary metabolism

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glyoxalate carbo-ligasegclYESTIGR01504 (HMM): glyoxylate carboligase
glycerate kinase ( (MANUAL)
tartronate semialdehyde reductase ( (HMM): 2-hydroxy-3-oxopropionate reductase
hydroxypyruvate isomerasehyiNOTIGR03234 (HMM): hydroxypyruvate isomerase

Parent Properties
GenProp0072central intermediary metabolism

Sibling Properties
GenProp0031methane utilization
GenProp0035Calvin cycle
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0120pentose phosphate cycle
GenProp0143Leloir pathway (galactose/glucose interconversion)
GenProp0196sulfur metabolism
GenProp0202nitrogen metabolism
GenProp0242phosphorus metabolism
GenProp0478acetyl-CoA -- acetate interconversion via acetyl phosphate
GenProp0479acetate -- acetyl-CoA interconversions
GenProp0865carbon fixation