Genome Property Definition Page
| Accession | GenProp0688 | |
| Name | urate catabolism to allantoin | |
| Type | PATHWAY | |
| Description | Urate is the product of xanthine catabolism by either the xanthine dehydrogenase complex (GenProp0640) or xanthine oxidase. The purine ring system of urate is oxidized by uricase (urate oxidase) and the 6-membered ring is opened by hydroxyisourate hydrolase. The hydrolase may be unnecessary in some organisms as the hydroxyisourate will hydrolyze spontaneously, albeit an a slow rate. The resulting product (OHCU) then spontaneously decarboxylates, resulting in a mixture of (S)- and (R)-allantoin. For further catabolism, generally only (S)-allantoin is processed, so allantoin racemace is also typically found. An OHCU carboxylase has been discovered in Mus musculus which does have homologs in prokaryotes. | |
| JCVI Role | Other | |
| Parent Property | GenProp0142: catabolism | |
| Literature References |
| |
| Gene Ontology Term | GO:0019628: urate catabolic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| hypothetical urate oxidase non-orthologous displacements | hyp_uox | NO | GENE_CLUST (MANUAL) | |
| urate oxidase (uricase, 1.7.3.3) | uox | YES | PF01014 (HMM): uricase | GO:0019628: urate catabolic process |
| OHCU decarboxylase | uraD | YES | TIGR03164 (HMM): OHCU decarboxylase TIGR03180 (HMM): OHCU decarboxylase | GO:0019628: urate catabolic process GO:0019628: urate catabolic process |
| hydroxyisourate hydrolase (3.5.2.17) | uraH | YES | TIGR02962 (HMM): hydroxyisourate hydrolase | GO:0019628: urate catabolic process |
| uraD N-terminal domain/upstream protein | uraX | NO | TIGR03212 (HMM): putative urate catabolism protein | GO:0019628: urate catabolic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0142 | catabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0055 | polyhydroxyalkanoic acids |
| GenProp0141 | galactose-6-phosphate degradation via tagatose-6-phosphate |
| GenProp0156 | cyanophycin-like storage polymers |
| GenProp0168 | glycogen system |
| GenProp0210 | phenylacetic acid catabolism |
| GenProp0231 | 4-hydroxyphenylacetate degradation |
| GenProp0233 | GABA utilization |
| GenProp0238 | 2-aminoethylphosphonate catabolism to acetaldehyde |
| GenProp0239 | propionyl-CoA catabolism |
| GenProp0241 | phosphonate catabolism |
| GenProp0271 | trehalose utilization |
| GenProp0272 | pyruvate fermentation to acetoin |
| GenProp0273 | protocatechuate degradation to beta-ketoadipate |
| GenProp0283 | beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA |
| GenProp0294 | ethanolamine degradation proteinaceous organelle |
| GenProp0457 | rhamnose catabolism |
| GenProp0458 | fucose catabolism |
| GenProp0461 | utilization of deoxynucleosides |
| GenProp0653 | ectoine catabolism |
| GenProp0674 | malonate decarboxylase |
| GenProp0686 | allantoin catabolism to glyoxalate and urea |
| GenProp0687 | allantoin catabolism to oxamate and carbamoyl-phosphate |
| GenProp0691 | glycolysis |
| GenProp0693 | fructose utilization as fructose-1,6-bisphosphate |
| GenProp0694 | glucose utilization as fructose-1,6-bisphosphate |
| GenProp0700 | purine catabolism via urate, xanthine and allantoin |
| GenProp0702 | benzoyl-CoA reductase |
| GenProp0703 | 4-hydroxybenzoyl-CoA reductase |
| GenProp0706 | cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway |
| GenProp0708 | catechol meta-cleavage pathway |
| GenProp0709 | benzoate catabolism BoxABC pathway |
| GenProp0711 | catechol ortho-cleavage upper pathway |
| GenProp0714 | galactarate utilization via tartronate semi-aldehyde |
| GenProp0715 | galactarate utilization via 2-oxoglutarate semialdehyde |
| GenProp0716 | glucarate utilization via tartronate semi-aldehyde |
| GenProp0717 | glucarate utilization via 2-oxoglutarate semialdehyde |
| GenProp0718 | oxalate degradation |
| GenProp0734 | amino acid catabolism |
| GenProp0749 | choline sulfate utilization |
| GenProp0760 | putrescine degradation to GABA via gamma-glutamylation |
| GenProp0763 | nicotinate fermentation to pyruvate and propionate |
| GenProp0810 | encapsulin proteinaceous organelle |
| GenProp0813 | pyrimidine utilization operon, RutABCDEFGR |
| GenProp0902 | quinohemoprotein amine dehydrogenase |
| GenProp1071 | myo-inositol catabolism |
| GenProp1072 | cyanase system |
| GenProp1076 | choline TMA-lyase system |