Genome Property Definition Page
| Accession | GenProp0630 |
| Name | 2-oxoglutarate dehydrogenase system |
| Type | SYSTEM |
| Description | This enzyme system utilizes three components E1 (thiamine pyrophosphate-binding subunit, SucA), E2 (dihydrolipoamide succinyltransferase, SucB) and E3 (dihydrolipoamide dehydrogenase, LpdA) for the interconversion of 2-oxoglutarate (alpha-ketoglutarate) and succinyl-CoA. In addition to lipoate and thiamine pyrophosphate, FAD is also involved. In the course of the reaction CO2 is released and and one molecule of NAD+ is converted to NADH. This reaction is an essential component of the TCA (Krebs) cycle. |
| JCVI Role | TCA cycle |
| Parent Property | GenProp0033: TCA cycle |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| thiamine pyrophosphate-binding subunit, SucA (E1) | E1 | YES | TIGR00239 (HMM): oxoglutarate dehydrogenase (succinyl-transferring), E1 component | |
| dihydrolipoamide succinyltransferase, SucB (E2) | E2 | YES | TIGR01347 (HMM): dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex TIGR02927 (HMM): 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase | |
| dihydrolipoamide dehydrogenase, LpdA (E3) | E3 | YES | TIGR01350 (HMM): dihydrolipoyl dehydrogenase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0033 | TCA cycle |