Genome Property Definition Page

Accession

GenProp0614

Name

cytochrome c oxidase, mitochondrial, caa3-type

Type

SYSTEM

Description

The cytochrome c oxidase complex is responsible for coupling the oxidation of the reduced cytochrome c protein to the reduction of molecular oxygen to form water with the concomitant pumping of protons out of the cell. This complex is the type found in mitochondria and prokaryotes which utilize mitochondrial-type aerobic respiration. The complex in Bacilli [2] is somewhat different but included here and carrys the gene symbols CtaD/CtaC.

JCVI Role

Electron transport

Parent Property

GenProp0615: cytochrome c based oxygen reduction and quinone re-oxidation

Literature References

[ 1 ]Ostermeier C, Harrenga A, Ermler U, Michel H Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10547-53. PMID 9380672
[ 2 ]Saraste M, Metso T, Nakari T, Jalli T, Lauraeus M, Van der Oost J The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme. Eur J Biochem. 1991 Jan 30;195(2):517-25. PMID 1847686

Components

Step Name	Step Num	Required	Evidence (Method)
oxidase subunit I CoxA/CtaD/Cox1	CoxA	YES	TIGR02891 (HMM): cytochrome c oxidase, subunit I
oxidase subunit II, CoxB	CoxB	YES	TIGR02866 (HMM): cytochrome c oxidase, subunit II
oxidase subunit III, CoxC	CoxC	YES	PF00510 (SUBFAMILY): cytochrome c oxidase subunit III TIGR02842 (SUBFAM-EX): cytochrome o ubiquinol oxidase, subunit III TIGR02897 (SUBFAM-EX): cytochrome aa3 quinol oxidase, subunit III
oxidase subunit IV, CoxD	CoxD	NO	TIGR02229 (HMM): caa(3)-type oxidase, subunit IV PF03626 (HMM): prokaryotic cytochrome c oxidase subunit IV
protoheme IX farnesyltransferase, CtaB/Cox10	CoxE?	NO	TIGR01473 (HMM): protoheme IX farnesyltransferase
assembly protein CoxG/CtaG/Cox11	CoxG	NO	PF04442 (HMM): cytochrome c oxidase assembly protein CtaG/Cox11
assembly protein CoxW/CtaA/Cox15	CoxW	NO	PF02628 (HMM): cytochrome oxidase assembly protein

Parent Properties

Accession	Name
GenProp0615	cytochrome c based oxygen reduction and quinone re-oxidation

Sibling Properties

Accession	Name
GenProp0483	cytochrome c oxidase, cbb3-type
GenProp0613	cytochrome c reductase