Genome Property Definition Page
| Accession | GenProp0543 |
| Name | TonB-dependent transport |
| Type | SYSTEM |
| Description | The components of a TonB-dependent transport system include ExbB, ExbD, and TonB, respectively homologous to TolQ, TolR, and TolA of related tol-pal system. But while the tol-pal system includes seven genes altogether, including the peptidoglycan associated lipoprotein Pal, and seems required for maintaining integrity of the outer membrane, TonB systems tend to be required for siderophore or B12 uptake when mutant phenotypes are observed. At least two different exbB/exbD gene pair families exist, and two different pairs of HMMs currently model two different classes. The capacity for TonB-dependent transport is also marked by the presence of TonB-dependent transporters, which share a region of homology and may number more than 50 in a single genome. |
| JCVI Role | Unknown substrate |
| Parent Property | GenProp0180: small molecule transport |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| TonB C-terminal domain | TonB | YES | TIGR01352 (HMM-CLUST): TonB family C-terminal domain | |
| barrel domain, tonB-dependent receptor | barrel | NO | PF00593 (HMM): TonB-dependent receptor | |
| tonB-system energizer ExbB | exbB | YES | TIGR02797 (HMM): tonB-system energizer ExbB TIGR02805 (HMM): tonB-system energizer ExbB | |
| tonB-system energizer ExbD | exbD | YES | TIGR02803 (HMM): TonB system transport protein ExbD TIGR02804 (HMM): TonB system transport protein ExbD | |
| plug domain, tonB-dependent receptor | plug | NO | PF07715 (HMM): TonB-dependent receptor plug domain |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0180 | small molecule transport |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0119 | PTS transport system |
| GenProp0129 | Na+-translocating NADH-quinone reductase |
| GenProp0135 | NADH dehydrogenase I |
| GenProp0172 | Potassium-transporting ATPase KdpFABC |
| GenProp0176 | TRAP-T (tripartite ATP-independent periplasmic transporters) family transporters |
| GenProp0190 | phosphate ABC transporter (pstSCAB-phoU) |
| GenProp0191 | sulfate/thiosulfate ABC transporter |
| GenProp0192 | molybdate ABC transporter |
| GenProp0236 | phosphonates ABC transport |
| GenProp0252 | thiamine/TPP ABC transporter ThiBPQ |
| GenProp0279 | cobalt import systems |
| GenProp0494 | nickel import ABC transporter |
| GenProp0542 | Tol-Pal system |
| GenProp0651 | ectoine ABC transporter EhuABCD |
| GenProp0693 | fructose utilization as fructose-1,6-bisphosphate |
| GenProp0694 | glucose utilization as fructose-1,6-bisphosphate |
| GenProp0712 | 2-aminoethylphosphonate (AEP) ABC transporter, type I, PhnSTUV |
| GenProp0721 | 2-aminoethylphosphonate (AEP) ABC transporter, type II |
| GenProp0743 | urea ABC transporter UrtABCDE |
| GenProp0748 | choline ABC transporter, ChoXWV family |
| GenProp0749 | choline sulfate utilization |
| GenProp0828 | heme uptake system, NEAT-domain mediated |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0873 | ion-motive antiporter cycles |