| Accession | GenProp0542 |
| Name | Tol-Pal system |
| Type | SYSTEM |
| Description | A complex of TolQ, TolR, and TolA in the inner membrane, interacting through TolA with a complex of TolB and Pal (also called OprL) present at the outer membrane, is pivotal to maintaining morphology and outer membrane integrity in many Gram-negative bacteria. The tol operon(s) routinely also contain ybgC (orf1) and ybgF (orf2) genes, although these are not clearly associated with mutant phenotypes. The TolA protein, homologous to TonB from a similar complex, is the most divergent, as it consists largely of very low complexity sequence. TolB contains a variable number of beta-propellar repeats. |
| Parent Property | GenProp0012: outer membrane
GenProp0180: small molecule transport
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| Literature References | [ 1 ]Sturgis JN Organisation and evolution of the tol-pal gene cluster. J Mol Microbiol Biotechnol. 2001 Jan;3(1):113-22. PMID 11200223
[ 2 ]Dubuisson JF, Vianney A, Hugouvieux-Cotte-Pattat N, Lazzaroni JC Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence. Microbiology. 2005 Oct;151(Pt 10):3337-47. PMID 16207916
[ 3 ]Llamas MA, Ramos JL, Rodriguez-Herva JJ Transcriptional organization of the Pseudomonas putida tol-oprL genes. J Bacteriol. 2003 Jan;185(1):184-95. PMID 12486055
[ 4 ]Zhuang Z, Song F, Martin BM, Dunaway-Mariano D The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis. FEBS Lett. 2002 Apr 10;516(1-3):161-3. PMID 11959124
[ 5 ]Cascales E, Lloubes R, Sturgis JN The TolQ-TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA-MotB. Mol Microbiol. 2001 Nov;42(3):795-807. PMID 11722743
[ 6 ]Cascales E, Lloubes R Deletion analyses of the peptidoglycan-associated lipoprotein Pal reveals three independent binding sequences including a TolA box. Mol Microbiol. 2004 Feb;51(3):873-85. PMID 14731286
[ 7 ]Llamas MA, Rodriguez-Herva JJ, Hancock RE, Bitter W, Tommassen J, Ramos JL Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane. J Bacteriol. 2003 Aug;185(16):4707-16. PMID 12896989
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| tol-pal system protein Pal (OprL) | Pal | YES | TIGR02802 (HMM): peptidoglycan-associated lipoprotein | |
| TolA | TolA | YES | TIGR02794 (HMM): protein TolA | |
| TolB | TolB | YES | TIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB | |
| TolQ | TolQ | YES | TIGR02796 (HMM): protein TolQ | |
| TolR | TolR | YES | TIGR02801 (HMM): protein TolR | |
| tol-pal region thioesterase YbgC | YbgC | NO | TIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase | |
| tol-pal region protein YbgF | YbgF | NO | TIGR02795 (HMM): tol-pal system protein YbgF | |
