Genome Property Definition Page
Accession | GenProp0481 | |
Name | urea carboxylase/allophanate hydrolase pathway | |
Type | PATHWAY | |
Description | This two-step, ATP-dependent pathway for urea hydrolysis is an alternative to urease. Urease requires a transporter and accessory proteins to produce its nickel metallocenter, while this two-step system uses biotin. Urea carboxylase acts first in this pathway, requiring ATP and bicarbonate as substrates. Allophanate hydrolase acts next, but note that this enzyme may be found in systems that do not contain a urea carboxylase. In yeasts such as Saccaromyces cerevisiae, the two activities of this pathway are encoded in a fusion protein, designated urea amidolyase. This pathway appears to function primarily for the purpose of obtaining nitrogen in the form of ammonia. A pair of uncharacterized, tandem, homologous genes, restricted to organisms with this system and adjacent to the known genes, has been added to this Genome Property. | |
JCVI Role | Nitrogen metabolism | |
Parent Property | GenProp0814: urea utilization | |
Literature References |
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Gene Ontology Term | GO:0043419: urea catabolic process (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
ABC transporter periplasmic binding protein, urea carboxylase region | ABC_bin | NO | TIGR03427 (HMM): ABC transporter periplasmic binding protein, urea carboxylase region | GO:0043419: urea catabolic process |
allophanate hydrolase | alloph | YES | TIGR02713 (HMM): allophanate hydrolase | GO:0043419: urea catabolic process |
urea carboxylase | uca | YES | TIGR02712 (HMM): urea carboxylase | GO:0043419: urea catabolic process |
urea carboxylase-associated protein 1 | unchar1 | YES | TIGR03424 (HMM): urea carboxylase-associated protein 1 | GO:0043419: urea catabolic process |
urea carboxylase-associated protein 2 | unchar2 | YES | TIGR03425 (HMM): urea carboxylase-associated protein 2 | GO:0043419: urea catabolic process |
Parent Properties
Accession | Name |
---|---|
GenProp0814 | urea utilization |
Sibling Properties
Accession | Name |
---|---|
GenProp0051 | urease |
GenProp0743 | urea ABC transporter UrtABCDE |