Genome Property Definition Page

Nameacetyl-CoA biosynthesis from acetate, direct
DescriptionThis property's sole component is the enzyme acetyl-CoA ligase which hydrolyses ATP to AMP in the process of ligating acetate to coenzyme A. This enzyme acts essentially irreversibly in the direction of AcCoA biosynthesis and utilizes an enzyme-bound acyl-adeylate (AMP-Ac) intermediate [1]. The purpose of this property is for comparison with the various other ways of interconverting acetate and acetyl-CoA.
Parent PropertyGenProp0479: acetate -- acetyl-CoA interconversions
Literature References
[ 1 ]BERG P  Acyl adenylates; an enzymatic mechanism of acetate activation.  J Biol Chem 1956 Oct;222(2):991-1013.  PMID 13367067
Gene Ontology TermGO:0019427: acetyl-CoA biosynthetic process from acetate (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
acetate--CoA ligaseligaseYESTIGR02188 (HMM): acetate--CoA ligaseGO:0019427: acetyl-CoA biosynthetic process from acetate

Parent Properties
GenProp0479acetate -- acetyl-CoA interconversions