Genome Property Definition Page

Nameacetyl-CoA -- acetate interconversion via acetyl phosphate
DescriptionAcetate and acetyl-CoA can be interconverted by any of several routes. This pathway utilizes acetyl phosphate as an intermediate. This system is used in E. coli and other bacteria for the utilization of acetate as a carbon source [1]. Alternatively, the reactions may be run in the catabolic direction in fermentations in order to produce ATP and excrete acetate. Detection of the phosphate acetyltransferase is via a TIGRFAMs equivalog in some cases, while in others the discrimination between substrate specificities for acetate and butyrate (PF01515) is unclear. In the absence of an equivalog hit, when a gene adjacent to the kinase and in an apparent operon and hits the PFAM subfamily and the genomic context does not otherwise indicate the handling of butyrate, the gene will be manually included. A member of PF01515 which is distal from the acetate kinase in Thermotoga has been experimentally characterized [3] and has also been manually included.
JCVI RoleOther
Parent PropertyGenProp0072: central intermediary metabolism
Literature References
[ 1 ]ROSE IA, GRUNBERG-MANAGO M, KOREY SR, OCHOA S  Enzymatic phosphorylation of acetate.  J Biol Chem 1954 Dec;211(2):737-56.  PMID 13221579
[ 2 ]Kumari S, Beatty CM, Browning DF, Busby SJ, Simel EJ, Hovel-Miner G, Wolfe AJ  Regulation of acetyl coenzyme A synthetase in Escherichia coli.  J Bacteriol 2000 Aug;182(15):4173-9.  PMID 10894724
[ 3 ]Bock AK, Glasemacher J, Schmidt R, Schonheit P  Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.  J Bacteriol 1999 Mar;181(6):1861-7.  PMID 10074080
Gene Ontology TermGO:0019427: acetyl-CoA biosynthetic process from acetate (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
phosphate acetyltransferaseAc-tranYESTIGR00651 (HMM): phosphate acetyltransferaseGO:0019427: acetyl-CoA biosynthetic process from acetate
acetyl kinasekinaseYESTIGR00016 (HMM): acetate kinaseGO:0019427: acetyl-CoA biosynthetic process from acetate

Parent Properties
GenProp0072central intermediary metabolism

Sibling Properties
GenProp0031methane utilization
GenProp0035Calvin cycle
GenProp0118ornithine biosynthesis from glutamate, acetylated branch
GenProp0120pentose phosphate cycle
GenProp0143Leloir pathway (galactose/glucose interconversion)
GenProp0196sulfur metabolism
GenProp0202nitrogen metabolism
GenProp0242phosphorus metabolism
GenProp0479acetate -- acetyl-CoA interconversions
GenProp0689glyoxalate conversion to phosphoglycerate
GenProp0865carbon fixation