• Genome Properties List
• Top Level Genome Properties

Genome Property Definition Page

Accession	GenProp0478
Name	acetyl-CoA -- acetate interconversion via acetyl phosphate
Type	PATHWAY
Description	Acetate and acetyl-CoA can be interconverted by any of several routes. This pathway utilizes acetyl phosphate as an intermediate. This system is used in E. coli and other bacteria for the utilization of acetate as a carbon source [1]. Alternatively, the reactions may be run in the catabolic direction in fermentations in order to produce ATP and excrete acetate. Detection of the phosphate acetyltransferase is via a TIGRFAMs equivalog in some cases, while in others the discrimination between substrate specificities for acetate and butyrate (PF01515) is unclear. In the absence of an equivalog hit, when a gene adjacent to the kinase and in an apparent operon and hits the PFAM subfamily and the genomic context does not otherwise indicate the handling of butyrate, the gene will be manually included. A member of PF01515 which is distal from the acetate kinase in Thermotoga has been experimentally characterized [3] and has also been manually included.
JCVI Role	Other
Parent Property	GenProp0072: central intermediary metabolism
Literature References	[ 1 ]ROSE IA, GRUNBERG-MANAGO M, KOREY SR, OCHOA S  Enzymatic phosphorylation of acetate.  J Biol Chem 1954 Dec;211(2):737-56.  PMID 13221579 [ 2 ]Kumari S, Beatty CM, Browning DF, Busby SJ, Simel EJ, Hovel-Miner G, Wolfe AJ  Regulation of acetyl coenzyme A synthetase in Escherichia coli.  J Bacteriol 2000 Aug;182(15):4173-9.  PMID 10894724 [ 3 ]Bock AK, Glasemacher J, Schmidt R, Schonheit P  Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.  J Bacteriol 1999 Mar;181(6):1861-7.  PMID 10074080
Gene Ontology Term	GO:0019427: acetyl-CoA biosynthetic process from acetate (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
phosphate acetyltransferase	Ac-tran	YES	TIGR00651 (HMM): phosphate acetyltransferase	GO:0019427: acetyl-CoA biosynthetic process from acetate
acetyl kinase	kinase	YES	TIGR00016 (HMM): acetate kinase	GO:0019427: acetyl-CoA biosynthetic process from acetate

Parent Properties

Accession	Name
GenProp0072	central intermediary metabolism

Sibling Properties

Accession	Name
GenProp0031	methane utilization
GenProp0035	Calvin cycle
GenProp0118	ornithine biosynthesis from glutamate, acetylated branch
GenProp0120	pentose phosphate cycle
GenProp0143	Leloir pathway (galactose/glucose interconversion)
GenProp0196	sulfur metabolism
GenProp0202	nitrogen metabolism
GenProp0242	phosphorus metabolism
GenProp0479	acetate -- acetyl-CoA interconversions
GenProp0689	glyoxalate conversion to phosphoglycerate
GenProp0865	carbon fixation