Genome Property Definition Page

Nameattenuation system: tryptophanase
DescriptionThis property is characterized by two components. One is the enzyme tryptophanase, capabable of degrading tryptophan. The other is the tryptophanase leader peptide, TnaC, encoded upstream of the enzyme. The ribosome that translates the leader peptide may stall at either of two points: the trp codon (when trp is scarce) or the stop codon. The leader peptide may interact with ribosome to delay release at its stop codon. Whether the ribosome stalls at the trp codon or continues to the stop codon controls what mRNA secondary structure may form as trytophanase message is synthesized. When trp is scarce, and the enzyme should not made, a terminator forms and transcription ends. Examples of this mechanism for controlling transcription at termination are called transcriptional attenuation.
JCVI RoleOther
Parent PropertyGenProp0551: regulatory systems
GenProp0734: amino acid catabolism
Literature References
[ 1 ]Konan KV, Yanofsky C  Regulation of the Escherichia coli tna operon: nascent leader peptide control at the tnaC stop codon.  J Bacteriol. 1997 Mar;179(5):1774-9.  PMID 9045840

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
tryptophanase TnaATnaAYESTIGR02617 (HMM): tryptophanase
tryptophanase leader pep TnaCleaderYESTIGR02616 (HMM): tryptophanase leader peptide

Parent Properties
GenProp0551regulatory systems
GenProp0734amino acid catabolism

Sibling Properties
GenProp0465circadian clock system KaiABC
GenProp0762chemotaxis response-regulator system
GenProp0849quorum-sensing, Bacillus PlcR-PapR system
GenProp0139degradation of tyrosine via homogentisate
GenProp0145histidine degradation to glutamate
GenProp0309arginine catabolism to glutamate via arginine succinyltransferase (AST)
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0659tryptophan degradation to anthranilate