| Accession | GenProp0314 |
| Name | CRISPR system, II/Nmeni subtype |
| Type | SYSTEM |
| Description | CRISPR repeats are by definition Clustered Regularly Interspaced Short Palindromic Repeats. The repeats vary in size from 24 to 48 bp, interspaced by similarly sized non-repetitive sequences. These spacers often are derived from phage and other exogenous DNA, are transcribed into RNA, and confer resistance to those same phage. Several CRISPR-associated sequences (cas genes) are nearly as widespread as CRISPR itself and nearly always are found near repeat loci. Others represent minor cas genes that serve as markers for specific subtypes of CRISPR/cas system, each with characteristic cas gene makeup, repeat structure, and spacer length. The Nmeni subtype, so named because this subtype is the only one found in the genome of Neisseria meningitidis, consists of cas1 and cas2 and the subtype specific genes csn1-2. This subtype has the most limited suite of cas core genes of any subtype defined thus far. The repeats associated with this subtype tend to have a periodicity of 66 nucleotides. This subtype is found only in Bacteria, and notably it would seem only in known or potential (i.e. containing virulence genes) vertebrate pathogens. |
| JCVI Role | Other |
| Parent Property | GenProp0021: CRISPR region
|
| Literature References | [ 1 ]Saunders NF, Goodchild A, Raftery M, Guilhaus M, Curmi PM, Cavicchioli R Predicted roles for hypothetical proteins in the low-temperature expressed proteome of the Antarctic archaeon Methanococcoides burtonii. J Proteome Res 2005 Mar-Apr;4(2):464-72. PMID 15822923
[ 2 ]Haft DH, Selengut J, Mo ngodin EF, Nelson KE A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput Biol. 2005 Nov;1(6):e60. PMID 16292354
|
|
| Accession | Name |
|---|
| GenProp0310 | CRISPR system, I-F/Ypest subtype |
| GenProp0313 | CRISPR system, I-C/Dvulg subtype |
| GenProp0315 | CRISPR system, I-E/Ecoli subtype |
| GenProp0316 | CRISPR system, III-B/RAMP module subtype |
| GenProp0317 | CRISPR system, I-B subtype, Tneap branch |
| GenProp0318 | CRISPR system, III-A/Mtube subtype |
| GenProp0319 | CRISPR system, I-A/Apern subtype |
| GenProp0320 | CRISPR system, I-B subtype, Hmari branch |
| GenProp0469 | CRISPR system, Dpsyc subtype |
| GenProp0670 | CRISPR system, Aferr subtype |
| GenProp0685 | CRISPR system, I-D/Cyano subtype |
| GenProp0768 | CRISPR system, Pging subtype |
| GenProp0922 | CRISPR system, Myxan subtype |
| GenProp1061 | CRISPR system, PreFran subtype |
