Genome Property Definition Page

Nametetrahydromethanopterin S-methyltransferase complex
DescriptionThis complex of eight subunits, MtrA-H, effects the transfer of a methyl froup from tetrahydromethanopterin to coenzyme M using a cobalamin (B12) cofactor residing on MtrA. This transfer is coupled to an energy-driven sodium-ion pump. Methane is subsequently released by a two-electron reduction of the methyl-coenzyme M by the enzyme methyl-coenzyme M reductase.
Parent PropertyGenProp0011: methanogenesis
GenProp0284: cobalamin-utilizing enzymes
Literature References
[ 1 ]Hippler B, Thauer RK  The energy conserving methyltetrahydromethanopterin:coenzyme M methyltransferase complex from methanogenic archaea: function of the subunit MtrH.  FEBS Lett 1999 Apr 23;449(2-3):165-8.  PMID 10338124

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
subunit A, cobalamin-containingMtrAYESTIGR01111 (HMM): tetrahydromethanopterin S-methyltransferase, subunit A
MtrBYESTIGR04166 (HMM): tetrahydromethanopterin S-methyltransferase, subunit B
MtrCYESTIGR01148 (HMM): tetrahydromethanopterin S-methyltransferase, subunit C
MtrDYESTIGR01112 (HMM): tetrahydromethanopterin S-methyltransferase, subunit D
MtrEYESTIGR01113 (HMM): tetrahydromethanopterin S-methyltransferase, subunit E
MtrFYESTIGR02507 (HMM): tetrahydromethanopterin S-methyltransferase, F subunit
MtrGYESTIGR01149 (HMM): tetrahydromethanopterin S-methyltransferase, subunit G
subunit H, pterin:cobalamin transferaseMtrHYESTIGR01114 (HMM): N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H

Parent Properties
GenProp0284cobalamin-utilizing enzymes

Sibling Properties
GenProp0719methyl-coenzyme M reductase
GenProp0722methanogenesis marker set
GenProp0290class II (B12-dependent) ribonucleotide reductase
GenProp0294ethanolamine degradation proteinaceous organelle