| Accession | GenProp0281 |
| Name | mannosylglycerate biosynthesis |
| Type | PATHWAY |
| Description | Mannosylglycerate is a compatible solute (cf. trehalose, ectoine, sucrose, glucosylglycerol, etc.) that tends to be found in highly thermophilic prokaryotes of various lineages. The more common biosynthetic pathway is a two-step pathway. Mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) combines GDP-mannose with 3-phospho-D-glycerate. The resultant mannosyl-3-phosphoglycerate is dephosphorylated by mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70). The two enzymes are fused in Dehalococcoides ethenogenes, a rare mesophile to have this pathway. |
| Parent Property | GenProp0267: osmolyte biosynthesis
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| Literature References | [ 1 ]Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for the synthesis of mannosylglycerate. Appl Environ Microbiol 2003 Jun;69(6):3272-9. PMID 12788726
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