Genome Property Definition Page

Accession

GenProp0280

Name

cobalt import system (CbtAB - proposed)

Type

SYSTEM

Description

The pair of genes making up this property have been proposed to comprise a cobalt ion imorter for the biosynthesis of vitamin B12 (cobalamin). Evidence for this assignment includes 1) prediction of five trans-membrane segments in CbtA and a single additional trans-membrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site in CbtB, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localization of CbtA and CbtB.

Parent Property

GenProp0279: cobalt import systems

Literature References

[ 1 ]Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes. J Biol Chem 2003 Oct 17;278(42):41148-59. Epub 2003 Jul 17. PMID 12869542

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
cobalt transporter subunit CbtA	CbtA	YES	TIGR02458 (HMM): cobalt transporter subunit CbtA (proposed)
cobalt transporter subunit CbtB	CbtB	YES	TIGR02459 (HMM): cobalt transporter subunit CbtB (proposed)

Parent Properties

Accession	Name
GenProp0279	cobalt import systems

Sibling Properties

Accession	Name
GenProp0277	cobalt import system (ABC transporter: 3.A.1.18.1)