Genome Property Definition Page

AccessionGenProp0269
Namecoenzyme B12 biosynthesis from cob(II)yrinate diamide
TypePATHWAY
DescriptionThis property covers the main branch of the latter part of the Coenzyme B12 (5-deoxyadenosyl cobalamin) biosynthesis pathway from cob(II)yrinate diamide which is the product of cobalt chelatase. Additionally, in order to have a complete pathway, an organism must have the capability to synthesize (or otherwise obtain) 1-amino-2-propanol and alpha-ribazole.
Parent PropertyGenProp0274: coenzyme B12 biosynthesis - overview

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
adenosylcobinamide-phosphate synthaseAcbPsynNOTIGR00380 (HMM): cobalamin biosynthesis protein CobD
cobyrinate adenosyltransferases (BtuR, PduO, EutT)CobAYESTIGR00708 (HMM): cob(I)yrinic acid a,c-diamide adenosyltransferase
TIGR00636 (HMM): ATP:cob(I)alamin adenosyltransferase
PF01923 (HMM): putative ATP:cob(I)alamin adenosyltransferase
alpha-ribazole-5`-phosphate phosphataseCobC/ZNOTIGR03161 (HMM): alpha-ribazole phosphatase CobZ
TIGR03162 (HMM): alpha-ribazole phosphatase
adenosylcobinamide synthase (CobD)CobDYESPF03186 (HMM): CobD/CbiB protein
cobyric acid synthase (CobQ/CbiP)CobQYESTIGR00313 (HMM): cobyric acid synthase CobQ
cobalamine 5-phosphate synthase (alpha ribazole transferase) (CobV)CobSYESPF02654 (HMM): cobalamin-5-phosphate synthase
TIGR00317 (HMM): cobalamin 5'-phosphate synthase
nicotinate nucleotide-DBI P-ribosyltransferaseCobTYESTIGR03160 (HMM): nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
bifunctional cobinamide kinase, cobinamide phosphate guanylyltransferase (CobP)CobUYESPF02283 (HMM): adenosylcobinamide kinase/adenosylcobinamidephosphate guanylyltransferase
threonine-phosphate decarboxylaseThrP_dcNOTIGR01140 (HMM): threonine-phosphate decarboxylase

Parent Properties
AccessionName
GenProp0274coenzyme B12 biosynthesis - overview


Sibling Properties
AccessionName
GenProp0113cobyrinic acid diamide biosynthesis, aerobic pathway
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0275cobyrinic acid diamide biosynthesis, anaerobic pathway
GenProp0277cobalt import system (ABC transporter: 3.A.1.18.1)