Genome Property Definition Page

Nametrehalose biosynthesis, TreYZ pathway
DescriptionTrehalose is an alpha,alpha glucose disaccharide that serves as a highly protective osmoprotectant in many species in all three domains of life. Trehalose may also be a component of more complex molecules such as cell wall glycolipids in Actinomycetes. The TreYZ is one of several pathways for trehalose biosynthesis and is dependent on the presence of glycogen-like glucose polymers. It is alternative to the OtsAB (osmotically regulated trehalose synthesis A and B) system. In some species with both, the TreYZ rather then the OtsAB system is induced by osmotic stress.
JCVI RoleBiosynthesis and degradation of polysaccharides
Parent PropertyGenProp0267: osmolyte biosynthesis
Literature References
[ 1 ]De Smet KA, Weston A, Brown IN, Young DB, Robertson BD  Three pathways for trehalose biosynthesis in mycobacteria.  Microbiology 2000 Jan;146 ( Pt 1):199-208.  PMID 10658666
[ 2 ]Elbein AD, Pan YT, Pastuszak I, Carroll D  New insights on trehalose: a multifunctional molecule.  Glycobiology 2003 Apr;13(4):17R-27R. Epub 2003 Jan 22.  PMID 12626396
Gene Ontology TermGO:0005992: trehalose biosynthetic process (biological_process)
GO:0006970: response to osmotic stress (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
maltooligosyltrehalose synthasetreYYESTIGR02401 (HMM): malto-oligosyltrehalose synthaseGO:0005992: trehalose biosynthetic process
GO:0006970: response to osmotic stress
malto-oligosyltrehalose trehalohydrolasetreZYESTIGR02402 (HMM): malto-oligosyltrehalose trehalohydrolaseGO:0005992: trehalose biosynthetic process
GO:0006970: response to osmotic stress

Parent Properties
GenProp0267osmolyte biosynthesis

Sibling Properties
GenProp0147glycine betaine biosynthesis from choline
GenProp0264glucosylglycerol biosynthesis
GenProp0265trehalose biosynthesis, OtsAB pathway
GenProp0268ectoine biosynthesis
GenProp0281mannosylglycerate biosynthesis
GenProp0878N(epsilon)-acetyl-beta-lysine biosynthesis
GenProp1070beta-glutamate biosynthesis