Genome Property Definition Page

Namepropionyl-CoA catabolism via methylcitric acid
DescriptionThis property describes one of at least five pathways for propionyl-CoA catabolism in prokaryotes. This pathway requires oxaloacetate and later releases succinate, both of which are TCA cycle intermediates. TCA cycle enzymes convert succinate back to oxaloacetate, and so this pathway is a cycle. Propionyl-CoA may derive from propionate, propionaldehyde, or other compounds. Propionyl-CoA plus oxaloacetate is converted by PrpC to 2-methylcitrate, which is then converted in two steps, by PrpD and an aconitase, to 2-methylisocitrate. 2-methylisocitrate is cleaved by PrpB to pyruvate and succinate. The TCA cycle enzymes needed to complete the cycle are not modelled here as part of the pathway
JCVI RoleAerobic
Parent PropertyGenProp0239: propionyl-CoA catabolism

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
2-methylisocitrate dehydrataseacnDYESTIGR02333 (HMM): 2-methylisocitrate dehydratase, Fe/S-dependent
methylisocitrate lyase PrpBprpBYESTIGR02317 (HMM): methylisocitrate lyase
2-methylcitrate synthase familyprpCYESTIGR01800 (HMM): 2-methylcitrate synthase/citrate synthase II
2-methylcitrate dehydrataseprpDYESTIGR02330 (HMM): 2-methylcitrate dehydratase
AcnD-accessory protein PrpFprpFYESTIGR02334 (HMM): probable AcnD-accessory protein PrpF
propionate catabolism operon regulator PrpRprpRNOTIGR02329 (HMM): propionate catabolism operon regulatory protein PrpR

Parent Properties
GenProp0239propionyl-CoA catabolism