Genome Property Definition Page
| Accession | GenProp0240 |
| Name | propionyl-CoA catabolism via methylcitric acid |
| Type | PATHWAY |
| Description | This property describes one of at least five pathways for propionyl-CoA catabolism in prokaryotes. This pathway requires oxaloacetate and later releases succinate, both of which are TCA cycle intermediates. TCA cycle enzymes convert succinate back to oxaloacetate, and so this pathway is a cycle. Propionyl-CoA may derive from propionate, propionaldehyde, or other compounds. Propionyl-CoA plus oxaloacetate is converted by PrpC to 2-methylcitrate, which is then converted in two steps, by PrpD and an aconitase, to 2-methylisocitrate. 2-methylisocitrate is cleaved by PrpB to pyruvate and succinate. The TCA cycle enzymes needed to complete the cycle are not modelled here as part of the pathway |
| JCVI Role | Aerobic |
| Parent Property | GenProp0239: propionyl-CoA catabolism |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| 2-methylisocitrate dehydratase | acnD | YES | TIGR02333 (HMM): 2-methylisocitrate dehydratase, Fe/S-dependent | |
| methylisocitrate lyase PrpB | prpB | YES | TIGR02317 (HMM): methylisocitrate lyase | |
| 2-methylcitrate synthase family | prpC | YES | TIGR01800 (HMM): 2-methylcitrate synthase/citrate synthase II | |
| 2-methylcitrate dehydratase | prpD | YES | TIGR02330 (HMM): 2-methylcitrate dehydratase | |
| AcnD-accessory protein PrpF | prpF | YES | TIGR02334 (HMM): probable AcnD-accessory protein PrpF | |
| propionate catabolism operon regulator PrpR | prpR | NO | TIGR02329 (HMM): propionate catabolism operon regulatory protein PrpR |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0239 | propionyl-CoA catabolism |