Accession | GenProp0152 |
Name | DNA dinucleotide thermophily metric RR+YY-RY-YR |
Type | CALCULATED |
Description | Kawashima, et al. (Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium) finds a linear relationship between optimal growth temperature (OGT) and the quantity J2, a measure of the tendency of consectutive nucleotides on one strand to both purines (RR) or both pymidines (YY). J2 is is the sum of the frequencies of consecutive purines (AA, AG, GA, GG) and consecutive pyrimidines (CC, CT, TC, TT) minus the frequencies of all other dinucleotide pairs (AC, AT, CA, CG, GC, GT, TA, TG). They report a best fit line to OGT = (293 x J2) + 46. |
Parent Property | GenProp0067: quantitative content
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Literature References | [ 1 ]Kawashima T, Amano N, Koike H, Makino S, Higuchi S, Kawashima-Ohya Y, Watanabe K, Yamazaki M, Kanehori K, Kawamoto T, Nunoshiba T, Yamamoto Y, Aramaki H, Makino K, Suzuki M. Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14257-62. PMID 11121031 |
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