Genome Property Definition Page
Accession | GenProp0137 | |
Name | iron-sulfur cluster assembly SUF system | |
Type | SYSTEM | |
Description | The iron-sulfur cluster assembly SUF system is one of three iron-sulfur assembly systems present in a wide range of bacteria, Archeae, and Plastids. The other two mechanisms for iron-sulfur cluster assembly are the ISC (iron-sulfur cluster) system, composed of at least six components and found broadly distributed from bacteria to higher eukaryotes, and the NIF (nitrogen fixation) system, which is required for nitrogenase maturation [1]. The SUF (mobilization of sulfur) system is composed of a six gene cluster with protein complexes responsible for cysteine desulfuration of sulfur atoms from cysteine, cytosolic ATPase activity, and a protein scaffold for iron and sulfur cluster assembly and transfer to protein targets [2]. Operational under stressful growth conditions, such as iron limitation and oxidative stress, the SUF system has been shown to be an important factor for bacterial pathogenicity [3]. | |
JCVI Role | Other | |
Parent Property | GenProp0140: iron-sulfur cluster assembly systems | |
Literature References |
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Gene Ontology Term | GO:0016226: iron-sulfur cluster assembly (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
iron-sulfur cluster assembly scaffold SufA | SufA | NO | TIGR01997 (HMM): FeS assembly scaffold SufA TIGR01994 (HMM): SUF system FeS assembly protein, NifU family | GO:0016226: iron-sulfur cluster assembly GO:0016226: iron-sulfur cluster assembly |
FeS assembly protein SufB | SufB | YES | TIGR01980 (HMM): FeS assembly protein SufB | GO:0016226: iron-sulfur cluster assembly |
cytosolic ATPase SufC | SufC | YES | TIGR01978 (HMM): FeS assembly ATPase SufC | GO:0016226: iron-sulfur cluster assembly |
FeS assembly protein SufD | SufD | YES | TIGR01981 (HMM): FeS assembly protein SufD | GO:0016226: iron-sulfur cluster assembly |
cysteine desulfurase auxiliary chain SufE | SufE | NO | PF02657 (HMM): Fe-S metabolism associated domain | GO:0016226: iron-sulfur cluster assembly |
transcriptional regulatory SufR | SufR | NO | TIGR02702 (HMM): iron-sulfur cluster biosynthesis transcriptional regulator SufR TIGR02944 (HMM): FeS assembly SUF system regulator | GO:0016226: iron-sulfur cluster assembly GO:0016226: iron-sulfur cluster assembly |
cysteine desulfurases, SufS subfamily | SufS | YES | TIGR01979 (HMM): cysteine desulfurase, SufS family | |
proteobacterial novel SUF protein SufT | novel | NO | TIGR02945 (HMM): FeS assembly SUF system protein TIGR03406 (HMM): probable FeS assembly SUF system protein SufT | GO:0016226: iron-sulfur cluster assembly GO:0016226: iron-sulfur cluster assembly |
Parent Properties
Accession | Name |
---|---|
GenProp0140 | iron-sulfur cluster assembly systems |
Sibling Properties
Accession | Name |
---|---|
GenProp0138 | iron-sulfur cluster assembly iscSUA-hscBA-fdx system |
GenProp0739 | iron-sulfur cluster assembly CsdA-CsdE system |
GenProp0742 | iron-sulfur cluster assembly NIF system |