Genome Property Definition Page

Nameiron-sulfur cluster assembly SUF system
DescriptionThe iron-sulfur cluster assembly SUF system is one of three iron-sulfur assembly systems present in a wide range of bacteria, Archeae, and Plastids. The other two mechanisms for iron-sulfur cluster assembly are the ISC (iron-sulfur cluster) system, composed of at least six components and found broadly distributed from bacteria to higher eukaryotes, and the NIF (nitrogen fixation) system, which is required for nitrogenase maturation [1]. The SUF (mobilization of sulfur) system is composed of a six gene cluster with protein complexes responsible for cysteine desulfuration of sulfur atoms from cysteine, cytosolic ATPase activity, and a protein scaffold for iron and sulfur cluster assembly and transfer to protein targets [2]. Operational under stressful growth conditions, such as iron limitation and oxidative stress, the SUF system has been shown to be an important factor for bacterial pathogenicity [3].
JCVI RoleOther
Parent PropertyGenProp0140: iron-sulfur cluster assembly systems
Literature References
[ 1 ]Takahashi Y, Tokumoto U.  A third bacterial system for the assembly of iron-sulfur clusters with homologs in archaea and plastids.  J Biol Chem. 2002 Aug 9;277(32):28380-3. Epub 2002 Jun 27.  PMID 12089140
[ 2 ]Loiseau L, Ollagnier-de-Choudens S, Nachin L, Fontecave M, Barras F.  Biogenesis of Fe-S cluster by the bacterial Suf system: SufS and SufE form a new type of cysteine desulfurase.  J Biol Chem. 2003 Oct 3;278(40):38352-9. Epub 2003 Jul 21.  PMID 12876288
[ 3 ]Nachin L, Loiseau L, Expert D, Barras F.  SufC: an unorthodox cytoplasmic ABC/ATPase required for [Fe-S] biogenesis under oxidative stress.  EMBO J. 2003 Feb 3;22(3):427-37.  PMID 12554644
Gene Ontology TermGO:0016226: iron-sulfur cluster assembly (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
iron-sulfur cluster assembly scaffold SufASufANOTIGR01997 (HMM): FeS assembly scaffold SufA
TIGR01994 (HMM): SUF system FeS assembly protein, NifU family
GO:0016226: iron-sulfur cluster assembly
GO:0016226: iron-sulfur cluster assembly
FeS assembly protein SufBSufBYESTIGR01980 (HMM): FeS assembly protein SufBGO:0016226: iron-sulfur cluster assembly
cytosolic ATPase SufCSufCYESTIGR01978 (HMM): FeS assembly ATPase SufCGO:0016226: iron-sulfur cluster assembly
FeS assembly protein SufDSufDYESTIGR01981 (HMM): FeS assembly protein SufDGO:0016226: iron-sulfur cluster assembly
cysteine desulfurase auxiliary chain SufESufENOPF02657 (HMM): Fe-S metabolism associated domainGO:0016226: iron-sulfur cluster assembly
transcriptional regulatory SufRSufRNOTIGR02702 (HMM): iron-sulfur cluster biosynthesis transcriptional regulator SufR
TIGR02944 (HMM): FeS assembly SUF system regulator
GO:0016226: iron-sulfur cluster assembly
GO:0016226: iron-sulfur cluster assembly
cysteine desulfurases, SufS subfamilySufSYESTIGR01979 (HMM): cysteine desulfurase, SufS family
proteobacterial novel SUF protein SufTnovelNOTIGR02945 (HMM): FeS assembly SUF system protein
TIGR03406 (HMM): probable FeS assembly SUF system protein SufT
GO:0016226: iron-sulfur cluster assembly
GO:0016226: iron-sulfur cluster assembly

Parent Properties
GenProp0140iron-sulfur cluster assembly systems

Sibling Properties
GenProp0138iron-sulfur cluster assembly iscSUA-hscBA-fdx system
GenProp0739iron-sulfur cluster assembly CsdA-CsdE system
GenProp0742iron-sulfur cluster assembly NIF system